IRCT2017102537002N1 IRCT 2017-11-14 None Evaluating a protocol of antibiotic prophylaxis to reduce bacterial contamination of the bone particles collected directly from the burs used for preparation of the dental implant site * The role of antibiotic prophylaxis in reducing bacterial contamination of autologous bone graft collected from implant site 2014-09-01 anticipated 30 Complete https://irct.ir/trial/27496 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Other design features: Although the patients are randomly allocated to the Test and Control groups, the study does not aim to evaluate any effects on health outcomes. The physiologically occurring bacterial contamination of bone particles produced during the preparation of the implant site does not represent a “health outcome” sensu stricto. Moreover, only a minimal part of the study is conducted in a clinical setting (the collection of bone particles during the implant site preparation), while the core of the study is performed in a laboratory setting. The operator performing surgical procedures and collection of bone particles, the laboratory workers assessing the microbiological outcomes, and authors involved in organizing and managing the analysis of data will be blinded to group assignment. N/A Bacterial contamination of autologous bone particles collected from dental implant site. Intervention 1: TEST Intervention: Antibiotic prophylaxis is prescribed to the Test group patients. One 1 gr. tablet of amoxicillin + clavulanic acid (Augmentin, GlaxoSmithKline, Verona, Italy) is given to the test group patients 12 hours and 1 hour before the surgery. All patients (Test and Control groups) will undergo the same surgical procedure (ie, implant site preparation). After local anesthesia, a full-thickness flap is made and the implant site is prepared with calibrated drills at 600 revolutions per minute, irrigated by cooled saline solution. During each step of the calibrated drills, bone particles on the coils are collected and placed in a 15 ml sterile tube containing 10 ml of prereduced thioglycolate broth. The collected samples are sent to the microbiology laboratory within one hour. Intervention 2: CONTROL Intervention: The Control group patients do not take antibiotic prophylaxis at all (No intervention). All patients (Test and Control groups) will undergo the same surgical procedure (ie, implant site preparation). It is described in the “TEST intervention” field.