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IRCT201506271159N17 IRCT 2017-09-15 Skin and Stem Cell Research Center, Maryam aley, South kamraneye, Tehran, Iran Efficacy assessment of cell therapy with autologous fibroblast in skin aging Transplantation of autologous skin fibroblast cells for treatment of nasolabial wrinkles 2016-10-06 anticipated 16 Complete https://irct.ir/trial/274 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. 1-2 Face wrinkles. First of all, fibroblast cells are isolated from biopsy of back region of patient’s ear, then ten million cells will be injected on each side of nasolabial fold for three times within 2 weeks interval. At the end, the rate of nasolabial fold improvement is estimated..
public Sona Zare
Skin and Stem Cell Research Center, Maryam aley, South kamraneye, Tehran, Iran
Tehran Iran (Islamic Republic of) 1937957511 +98 21 2220 1710 sonazarebio@gmail.com Skin and Stem Cell Research Center of Tehran University of Medical sciences scientific Dr. Mohammadali Nilforoushzade
Skin and Stem Cell Research Center, Maryam aley, South kamraneye, Tehran, Iran
Tehran Iran (Islamic Republic of) 1937957511 +98 21 2220 1710 dr_nilforoush@yahoo.com Skin and Stem Cell Research Center of Tehran University of Medical sciences Iran (Islamic Republic of) Inclusion criteria: age about 35 to 55 years old;- Patients with mild to moderate wrinkles according to Glogue scale I-III; No coagulation disorders and use of anti coagulated drugs; No infection in treated site; No fever able diseases; No chronic liver diseases; No pregnancy or breast-feeding; Having no anatomic disorder in face; Normal mental health; Having a good cooperation with research team. Exclusion Criteria: being smokers or drinkers; any past skin intervention in face; Having many wrinkles on the face; type of 1 or 5 of wrinkle scoring; having a mental disorder; having an obsessed disorder; having any skin disorder; having any major disorder; having a systemic disorder; having an oral disorder; 35 years 55 years Both L98.8 Other specified disorders of skin and subcutaneous tissue Other First of all, fibroblast cells are isolated from biopsy of back region of patient’s ear, then ten million cells will be injected on each side of nasolabial fold for three times within 2 weeks interval. At the end, the rate of nasolabial fold improvement is estimated. Severity of face wrinkles. Timepoint: 1- 3 - 6 Month after cell therapy. Method of measurement: Biometry with visioface & skin sonography. Skin and Stem Cell Research Center, Maryam aley, South kamraneye, Tehran, Iran Approved 2014-09-29 Tehran University of Medical sciences Tehran University of Medical Sciences, Cross Qods st, Keshavarz Blvd, Tehran, Iran Tehran Iran (Islamic Republic of)