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IRCT2017100236514N1 IRCT 2017-10-16 Shahid Beheshti University of Medical Sciences Effect of chemotherapy and chemoradiotherapyon stomach cancer Evaluation of induction chemotherapy and Neoadjuvant chemoradiotherapy effect on pathologic complete response in cardia and gastric cancer 2017-08-23 anticipated 30 Complete https://irct.ir/trial/27273 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. N/A Gastric and cardiac cancer. They will receive induction chemotherapy at first (paclitaxel 50 mg/m2, carboplatin AUC=2، weekly for 12 courses), then concurrent neoadjuvant chemoradiotherapy (RT/Radiotherapy 45Gy/25frc، oxaliplatin 40mg/m2 weekly and capecitabin 500mg/m2/BID daily during overall tretment time). 6_8 weeks after completion of neoadjuvant treatment they will undergo surgery.
public Dr. Ali Yaghoobi jooybari
Emam Hossein squad, Shahid Madani avenue
Tehran Iran (Islamic Republic of) +98 21 73430 dryaghobii@yahoo.com Shahid Beheshti University of Medical Sciences, Emam Hossein hospital scientific Dr. Payam Azadeh
Emam Hossein square, shahid madani avenue
Tehran Iran (Islamic Republic of) +98 21 73430 dr_azadeh@sbmu.ac.ir Shahid Beheshti University of Medical Sciences, Emam Hossein hospital Iran (Islamic Republic of) Inclusion criteria: stomach or cardiac cancer; resectable locally advanced Timor (T3 or T4 with pricardial or pleural or diaphragmatic involvement, or N1 and more); no metastasis; ages 18_75; normal liver and renal function test; performance statues (ps) 0_1. Exclusion criteria: T1_2 N0, unresectable tumors(T4b); peritoneal or visceral metastasis; non regional lymph node extension such as paraaortic or mesantric; age <18 or >75; impaired liver or renal function test and PS 2 and more. 18 years 75 years Both C16 Malignant neoplasm of stomach Treatment - Drugs They will receive induction chemotherapy at first (paclitaxel 50 mg/m2, carboplatin AUC=2، weekly for 12 courses), then concurrent neoadjuvant chemoradiotherapy (RT/Radiotherapy 45Gy/25frc، oxaliplatin 40mg/m2 weekly and capecitabin 500mg/m2/BID daily during overall tretment time). 6_8 weeks after completion of neoadjuvant treatment they will undergo surgery Pathologic complete response. Timepoint: 6_8 weeks after completion of them I radiotherapy, in surgical specimen. Method of measurement: microscopic assessment of surgical specimen by pathologist. Surgical margin. Timepoint: after intervention, in surgical specimen. Method of measurement: microscopic assessment of surgical specimen by pathologist. Shahid Beheshti University of Medical Sciences Approved 2017-08-08 School of Medicine, Shahid Beheshti University of Medical Sciences Shahid Beheshti University of Medical Sciences, Velenjak, Chamran highway Tehran Iran (Islamic Republic of)