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IRCT20170915036192N2 IRCT 2018-11-27 Mashhad University of Medical Sciences The effect of oral magnesium sulfate in asthma The effect of oral magnesium sulfate on moderate and severe asthmatic attack in children aged 5-12 years old referred to emergency department of Ghaem Hospital 2015-08-23 anticipated 40 Complete https://irct.ir/trial/27124 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Participants of the study were selected by convenient sampling from those patients who referred to the emergency department of Ghaem hospital in Mashhad .As these patients arrived they were randomly assigned to one of control or Intervention groups by lot, Blinding description: In this study the pharmacist knew the nature of the drug or placebo while the Investigator and patients were unaware of its nature . N/A astma. Intervention 1: Intervention group: 300 mg capsules of magnesium sulfate were given to patients in this group every 12 hours for 5 days. Intervention 2: Control group: Placebo capsules with the same shape, color and smell were given to the patients every 12 hours for 5 days. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is "No more information"
public Melika Zarei Sani
Azad Square, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mashhad Iran (Islamic Republic of) 9177948564 +98 51 3882 8888 zareism931@mums.ac.ir Mashhad University of Medical Sciences scientific Hamid Ahanchian
Mashhad University of Medical Sciences
Mashhad Iran (Islamic Republic of) 9176699199 +98 51384000019 AhanchianH@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Asthma attack diagnosis based on history and clinical examination of patients diagnosed asthma by asthma specialist.modrate and severe asthma attacks in asthmatic children aged 5 to 12 years. The consent of the child and his legal guardian to enter the study. 5 years 12 years Both Exclusion criteria: Mild asthma attacks that could be treated on an outpatient basis and at home. The presence of other chronic underlying conditions other than asthma, such as heart disease, renal or pulmonary disease. The use of drugs that affects the magnesium absorption and secretion mechanism include diuretics, digoxin, calcium supplements. Failure to use the drug by the patient and lack of proper follow up by the parent. Severe complications of the drug J45 Asthm Placebo Placebo Intervention group: 300 mg capsules of magnesium sulfate were given to patients in this group every 12 hours for 5 days. Control group: Placebo capsules with the same shape, color and smell were given to the patients every 12 hours for 5 days. Improve the symptoms of asthma. Timepoint: At the time of visit, 2,6,24 hours after the visit, and daily for up to 5 days. Method of measurement: quetionnary. The speed of symptom improvement. Timepoint: When visiting, after 2 hours, 6 hours and 24 hours of referral, and then daily for up to 5 days. Method of measurement: questionnaire. Mashhad University of Medical Sciences Approved 2016-07-13 The Ethics Committee in medical research of Mashhad University of Medical Sciences Azad Square, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Khorasan Razavi Razavi Khorasan Iran (Islamic Republic of)