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IRCT2017090936103N1 IRCT 2017-11-18 Shahed University Comparison of oral consumption of pomegranate peel and Mefenamic Acid on Efrat tams disease Comparison of oral consumption extract hydrophilia of pomegranate peel and Mefenamic Acid on menorrahagia disease 2017-11-22 anticipated 60 Complete https://irct.ir/trial/27086 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Menorrhagia. Intervention 1: Intervention 1. A 250 mg capsule extract of pomegranate peel is consumed after each meal in 7 days of menstruation for three cycles. Intervention 2: Intervention 1. A 250 mg capsule of Mefenamic Acid is consumed after each meal in 7 days of menstruation for three cycles.
public Gholamreza Salsali
Shahed University, in front of the shrine Imam Khomeini (RA), Persian Gulf Highway
Tehran Iran (Islamic Republic of) 3319118651 +98 21 5121 3565 gh.salsali@shahed.ac.ir Shahed University scientific Nafise Zafarghandi
Shahed University, in Front of Imam Khomeini Holy Shrine, Persian Gulf Highway
Tehran Iran (Islamic Republic of) 3319118651 +98 212151210 nafis_zafar@ymail.com Shahed University Iran (Islamic Republic of) Inclusion criteria: Patients with high or long uterine bleeding who have had a negative pregnancy test; and are not breast-feeding; in ultrasonography their thickness of endometrium is normal; there is no mass of adnexa and ovaries except for a simple cyst less than two centimeters; genecology examination and Pap smear tests are normal; they’re not taking other hormonal and anticoagulant drugs like aspirin; or herbal drugs and teas; they do not have systemic or organic diseases and bleeding disorders; In the ultrasound the size of the uterus is less than 10 cm; there is no submucosal or intramural fibroma; and sub-serous fibroma is not bigger than 4 cm; they do not use IUD; and do not have BMI greater than 30; CBC and Hb are not less than 10. Exclusion criteria: Taking hormonal drugs during the study; experiencing possible side effects like anemia (Hb less than 10); needing surgery or other interventions; leaving the study on personal requests; requiring emergency procedures during the study due to severe bleeding; occurrence of pregnancy; and experiencing serious side effects due to the drugs. 20 years 50 years Female N92.0 excessive and frequent menstruation with regular cycle Treatment - Drugs Treatment - Drugs Intervention 1. A 250 mg capsule extract of pomegranate peel is consumed after each meal in 7 days of menstruation for three cycles. Intervention 1. A 250 mg capsule of Mefenamic Acid is consumed after each meal in 7 days of menstruation for three cycles. Bleeding Volume. Timepoint: One month before, first, second and third month after intervention. Method of measurement: Pictorial Blood Loss Assessment Chart. Bleeding Volume. Timepoint: One month before, first, second and third month after intervention. Method of measurement: Pictorial Blood Loss Assessment Chart. Hb level. Timepoint: Before and 3 months after intervention. Method of measurement: Lab test. Quality of life. Timepoint: Before and 3 months after intervention. Method of measurement: Menorrhagia questionnaire. Shahed University Approved 2017-10-30 Ethics Committee of Shahed University Shahed University, in front of the shrine Imam Khomeini (RA), Persian Gulf Highway Tehran Iran (Islamic Republic of)