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IRCT2017083035991N1 IRCT 2017-10-25 Vice-chancellor for Research, Tehran University of Medical Sciences A comparison of two methods to prevent cardiac muscle damage during cardiopulmonary bypass surgery Investigation of the changes in cardiac muscle damage marker and serum lactate in pateints undergoing cardiopumonary bypass using the del Nido cardioplegia versus Custodiol: A pilot study 2017-10-23 anticipated 40 Complete https://irct.ir/trial/27041 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Other design features: Blinding will be done on patients and outcome assessors (nurses registering the clinical outcomes and laboratory personnel). They will be unaware of the patients' allocation sequence. N/A Coronary artery bypass graft surgery. Intervention 1: del Nido cardioplegia. Intervention 2: Custodial cardioplegia.
public Mohammad Javad Mehranbaniyan
Surgery Department, Thran Heart Center, Nort Kargar St
Tehran Iran (Islamic Republic of) +218 8029203 mehrabanian56@gmail.com Tehran Heart Center scientific Mehdi Dehghani Firoozabadi
Surgery Department, Thran Heart Center, Nort Kargar St
Tehran Iran (Islamic Republic of) +218 8029203 mdfiroozabadi834@yahoo.commdfiroozabad@sina.tums.ac.ir Tehran Heart Center Iran (Islamic Republic of) Inclusion criteria: patients undegoing coronary artery bypass and valve graft surgery, informed satisfaction. Exclusion criteria: diagnosed inflammatory diseases before surgery, acute myocardial infarction, patient dissatisfaction, dialysis-requiring renal failure, ejection fraction less than 15%, second surgery, emergency patients, predictive pulmonary disease patients, cardiomyopathy patients. no limit 80 years Both T82.9 Unspecified complication of cardiac and vascular prosthetic device, implant and graft Treatment - Surgery Treatment - Surgery del Nido cardioplegia Custodial cardioplegia Cardiac Troponin I. Timepoint: Before operation, after operation and 24 hours after operation. Method of measurement: ng/ml using enzyme immunoassay. Serum Lactate. Timepoint: Prior to the Coronary artery bypass graft surgery, Immediate post aortic declamping, At the entrance to the ICU, 6, 12, and 24 hours post entrance to the ICU. Method of measurement: Biochemical analyzer. Hemoglobin. Timepoint: Before operation, after operation and 24 hours after operation. Method of measurement: Hematology analyzer. Hematocrit. Timepoint: Before operation, after operation and 24 hours after operation. Method of measurement: Hematology analyzer. Platelet count. Timepoint: Before operation, after operation and 24 hours after operation. Method of measurement: Hematology analyzer. Vice-chancellor for Research, Tehran University of Medical Sciences Approved 2017-09-17 Research Ethics Committee of Tehran University of Medical Sciences 16 Azar St, Enghelab Sq, Tehran Province Tehran Iran (Islamic Republic of)