IRCT20170829035966N1 IRCT 2018-01-17 Vice Chancellor for research of Birjand University of Medical Sciences Efficacy of Laughter Yoga and anti-anxiety drugs on irritable bowel syndrome Comparison of Laughter Yoga and anti-anxiety medication on anxiety and gastrointestinal symptoms of patients with irritable bowel syndrome 2018-01-21 anticipated 60 Complete https://irct.ir/trial/27026 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomizashin by sealed envelope. 2 Irritable Bowel Syndrome. Intervention 1: Intervention in the first intervention group:Laughter Yoga:Laughter Yoga combines unconditional laugh with yoga breathing and yoga stretching exercises, and people laughing without any jokes. Meetings will be held once a week. there are seven Meetings of stress management therapy by Laughter Yoga, each meetings duration are one hour, a first meeting is justification of Laughter Yoga for participants, and the next five meetings are training and practice of laughing techniques, and the last meeting is practice and repetition of training of the previous one will be. Severity scorring system of irritable bowel syndrome designed by Francis CY in 1997. Mild (score 8 to 18), moderate (score 18 to 30) and severe (above 30). Intervention 2: Intervention in the second intervention group: Anti-anxiety treatment: Sertraline, 50 mg orally once a day for seven weeks. Intervention 3: Control group: Symptomatic treatment with loperamide and hyoscine Loperamide: 2 mg orally three to four times a day for seven weeks Hyoscine: 20 mg orally four times a day for seven weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more informations