]>
IRCT2017080135408N1 IRCT 2017-08-12 Research Center for Infectious Diseases of the Digestive System, Vice Chancellor research of Ahvaz J The influence of probiotics and Zinc on the patients with non-alcoholic fatty liver disease The influence of probiotics and Zinc on the serum levels of liver enzymes and lipid profile in patients with non-alcoholic fatty liver disease 2016-12-05 anticipated 128 Complete https://irct.ir/trial/26762 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A Non-alcoholic fatty liver disease. Intervention 1: Two protexin probiotic capsules 600 mg (Probiotics international, United Kingdom) and two zinc sulfate capsules 25 mg (Alhavi, Iran)are used daily, at noon and at night after meals, for three months. The protexin capsule contains 7 species of probiotics. Include Lactobacillus casei, Lactobacillus rhamnosus, Streptococcus thermophilus, Lactobacillus acidophilus, Bifidobacterium breve, Bifidobacterium longum and Lactobacillus bulgaricus. Intervention 2: Two protexin probiotic capsules 600 mg (Probiotics international, United Kingdom) and two zinc placebo capsules are used daily, at noon and at night after meals, for three months. The protexin capsule contains 7 species of probiotics. Include Lactobacillus casei, Lactobacillus rhamnosus, Streptococcus thermophilus, Lactobacillus acidophilus, Bifidobacterium breve, Bifidobacterium longum and Lactobacillus bulgaricus. Intervention 3: Two capsules of probiotic placebo and two zinc sulfate capsules 25 mg (Alhavi, Iran) are used daily, at noon and at night after meals, for three months. Intervention 4: Two probiotic placebo capsules and two zinc placebo capsules are used daily, at noon and at night after meals, for three months.
public Dr Masoumeh Khedri
Ahvaz Jundishapur University of Medical Sciences
Ahvaz Iran (Islamic Republic of) +98 61 3221 6104 khedri.m@ajums.ac.ir Ahvaz Jundishapur University of Medical Sciences scientific Dr Masoumeh Khedri
Ahvaz Jundishapur University of Medical Sciences
Ahvaz Iran (Islamic Republic of) +98 61 3221 6104 khedri.m@ajums.ac.ir - khedrimasoumeh@gmail.com Ahvaz Jundishapur University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Patients with non-alcoholic fatty liver disease Exclusion criteria: autoimmune hepatitis- viral hepatitis- liver metabolic diseases- liver metabolic disease- drugs and toxins inception- age below 18- History of receiving medication for NAFLD- History of kidney or heart disease- Taking amiodarone, methotrexate, tamoxifen, glucocorticoids, sodium valproate and anti HIV drugs. 18 years 90 years Both K76.0 K76.0 Treatment - Drugs Treatment - Other Treatment - Other Placebo Two protexin probiotic capsules 600 mg (Probiotics international, United Kingdom) and two zinc sulfate capsules 25 mg (Alhavi, Iran)are used daily, at noon and at night after meals, for three months. The protexin capsule contains 7 species of probiotics. Include Lactobacillus casei, Lactobacillus rhamnosus, Streptococcus thermophilus, Lactobacillus acidophilus, Bifidobacterium breve, Bifidobacterium longum and Lactobacillus bulgaricus. Two protexin probiotic capsules 600 mg (Probiotics international, United Kingdom) and two zinc placebo capsules are used daily, at noon and at night after meals, for three months. The protexin capsule contains 7 species of probiotics. Include Lactobacillus casei, Lactobacillus rhamnosus, Streptococcus thermophilus, Lactobacillus acidophilus, Bifidobacterium breve, Bifidobacterium longum and Lactobacillus bulgaricus. Two capsules of probiotic placebo and two zinc sulfate capsules 25 mg (Alhavi, Iran) are used daily, at noon and at night after meals, for three months. Two probiotic placebo capsules and two zinc placebo capsules are used daily, at noon and at night after meals, for three months. ALT. Timepoint: Before and 3 months after intervention. Method of measurement: Blood test. AST. Timepoint: Before and 3 months after intervention. Method of measurement: Blood test. FBS. Timepoint: Before and 3 months after intervention. Method of measurement: Blood test. Total cholesterol. Timepoint: Before and 3 months after intervention. Method of measurement: Blood test. Triglyceride. Timepoint: Before and 3 months after intervention. Method of measurement: Blood test. HDL. Timepoint: Before and 3 months after intervention. Method of measurement: Blood test. LDL. Timepoint: Before and 3 months after intervention. Method of measurement: Blood test. CRP. Timepoint: Before and 3 months after intervention. Method of measurement: Blood test. Weight. Timepoint: Before and 3 months after intervention. Method of measurement: Scale. Body mass index (BMI). Timepoint: Before and 3 months after intervention. Method of measurement: Body mass is expressed in units of kg/m2. Waist. Timepoint: Before and 3 months after intervention. Method of measurement: Centimeter. Research Center for Infectious Diseases of the Digestive System, Vice Chancellor research of Ahvaz J Approved 2016-10-22 Ethics committee of Ahvaz Jundishpour University of Medical Sciences Khuzestan, Ahvaz, Golestan, Ahvaz Jundishpour University of Medical Sciences Ahvaz Iran (Islamic Republic of)