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IRCT20170716035117N1 IRCT 2018-01-01 Kashan University of Medical Sciences Effect of Aripiprazole and Risperidone in Improving Obsessive-compulsive symptoms in Bipolar patients Comparison of the Effectiveness of Aripiprazole and Risperidone in Improving Obsessive-compulsive symptoms in Bipolar patients Comorbid Obsessive-compulsive disorder 2017-07-11 anticipated 60 Complete https://irct.ir/trial/26636 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Random assignment will be done by the use of computer-generated random numbers, Blinding description: Double-blind (both patients and researchers) in your study are blinded. 3 Condition 1: Obsessive-compulsive disorder. Condition 2: Bipolar disorder. Intervention 1: First intervention group: In addition to peptic stabilizers, aripiprazole is started at a dose of 2.5 mg and gradually administered to the end of the second week to 10 mg per day. The duration of use is 12 weeks. Intervention 2: Intervention group2:In addition to mood stabilizers, Risperidone was started by 1 mg and gradually received 2 mg / day until the end of the first week.Duration of use is 12 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is The release plan is still unknown
public Fatemesadat Qoreishi
Kargar Nejad Hospital, Qotb Ravandi Blvd
Kashan Iran (Islamic Republic of) 8715973446 +98 31 5554 9111 dr.zoghoreishi@yahoo.com Kashan University of Medical Sciences scientific Fateme Sadat Qoreishi
Kargar nejad Hospital, Qotb Ravandi Blvd
Kashan Iran (Islamic Republic of) 8715973446 +98 31 5554 9111 dr.zoghoreishi@yahoo.com Kashan University of Medical Sciences Iran (Islamic Republic of) age between 18 and 65 years A definitive diagnosis of Bipolar disorder with Obsessive-compulsive disorder based on DSM-5 criteria Bipolar patients in Maintenance phase Patients with ability to answer and evaluate with Yale Brown scale (Higher education level) Patients with Yale-Brown Obsessive-Compulsive Scale 16 or higher 18 years 65 years Both Acute and severe physical illness during study Presence of unsafe pregnancy prevention method in women of reproductive age Pregnancy Bearst feeding Substance abuse and alcohol abuse in the six months before study Accompanied with other psychiatric disorders F42 F31 Obsessive-compulsive disorder Bipolar disorder Treatment - Drugs Treatment - Drugs First intervention group: In addition to peptic stabilizers, aripiprazole is started at a dose of 2.5 mg and gradually administered to the end of the second week to 10 mg per day. The duration of use is 12 weeks. Intervention group2:In addition to mood stabilizers, Risperidone was started by 1 mg and gradually received 2 mg / day until the end of the first week.Duration of use is 12 weeks. Severity obsessive compulsion. Timepoint: The beginning of the study and every four weeks until the twelfth week. Method of measurement: Yale Brown Obsessive-Compulsion Scale. The onset of side effects of drugs. Timepoint: Weeks four, eighth, twelfth. Method of measurement: Clinical examination. Kashan University of Medical Sciences Approved 2017-05-16 Ethics committee of Kshan University of Medical Sciencesa Ghotbe Ravand Boulevard, Kashan University of Medical Sciences Kashan Isfehan Iran (Islamic Republic of)