IRCT2017070934981N1 IRCT 2017-07-16 Vice chancellor for research, Zahedan University of Medical Sciences The effect of estrogen and misoprostol on abortion Comparison of induction of abortion in the first trimester using misoprostol and misoprostol with estrogen priming 2017-07-23 anticipated 100 Complete https://irct.ir/trial/26580 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Abortion. In this study, the aim of this study was to examine the induction of abortion in the first trimester using misoprostol and misoprostol with estrogen priming, randomly divided into two groups receiving misoprostol and misoprostol with estrogen priming. In the misoprostol-containing group, this medication at 800 μg every 8 hours (4 pills 200 μg) will be placed vaginal in the posterior foreskin (up to a maximum dose of 2400 μg), followed by side effects of fever, sweating, fatigue, Nausea, vomiting, abdominal pain ... and the time taken to remove tissue and will be recorded in the patient's case. Four hours after the removal of the tissue, ultrasound is performed for the patient and if the pregnancy remains below 10 mm, the abortion is considered successful and if the remains are more than 10 mm, the curettage will be performed for the patient. . In the misoprostol group with estrogen priming, we will also work on the misoprostol group, with the exception that in this group, the first dosage of misoprostol will be given to the patient with oral estrogen valerima with a dose of 2 mg and the study will continue to be similar to that of the previous group. were..