IRCT20170614034532N2 IRCT 2018-06-11 Tehran University of Medical Sciences Colistin loading dose in pediatrics Comparing efficacy and safety of Colistin Loading dose regimen versus Conventional regimen in improving clinical and microbiological response for the treatment of multidrug resistant gram-negative infections in pediatrics 2018-07-23 anticipated 40 Complete https://irct.ir/trial/26366 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The Method for randomization in this RCT is permuted block randomization. The unit of randomization is persons. The tool for randomization is random number table, Blinding description: In this study after Obtaining consent letter from the child's parents,the child will be randomly placed in one of the interventional or control group.Since the researcher and the physician and nurse that are responsible for the patients know that the child is receiving Colistin loading dose or not ,so the study is single blind. 3 Condition 1: bloodstream infections. Condition 2: Ventilator Associated Pneumonia. Intervention 1: Intervention group: Patients receive a loading dose of 150,000 IU/Kg.The loading dose is followed by 50,000 IU every 8 hours. Clinical, microbiological and laboratory findings are collected for each patient on 1th and 4th day after treatment.The Nephrotoxicity is assessed based on PRIFLE recommendation on day 4 after treatment. Intervention 2: Control group:Patients receive Colistin at the dose of 50,000 IU every 8 hours. Clinical, microbiological and laboratory findings are collected for each patient on 1th and 4th day after treatment.The Nephrotoxicity is assessed based on PRIFLE recommendation on day 4 after treatment. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no more innformation