IRCT2017052134062N1 IRCT 2017-07-23 Vice chancellor for research, Zahedan University of Medical Sciences The effect of dehydroepiandrosterone on quality of life Evaluation the effect of DHEA (dehydroepiandrosterone) on quality of life and disease activity in women with Rheumatoid Arthritis 2017-06-22 anticipated 46 Complete https://irct.ir/trial/26142 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: Randomization and blinding: Firstly, the resident will select 46 patients based on inclusion and exclusion criteria and introduce them to an educated nurse. The nurse will randomly, by using permuted block randomization, assign the patients into DHEA and placebo groups and register their names and the allocated group and then will write the names of patients of DHEA group on the DHEA drugs boxes and the names of patients of placebo group on the placebo boxes and will give the boxes to the resident to deliver the boxes to the patients; therefore, the resident is blinded (DHEA drugs and placebo boxes have a similar appearance). Considering that the boxes have a similar appearance, the patients are also blinded ( When giving a written consent, it will be explained to the patients that for improving the accuracy of the results, the patients should be blinded but they are either in DHEA or placebo group. The cons and pros of each treatment option will be explained). N/A rheumatoid arthritis. Intervention 1: DHEA group: 50 mg oral tablets once a day for three months. Intervention 2: Placebo group: daily oral tablets containing starch for thee months.