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IRCT2017052034046N1 IRCT 2017-06-17 Vice Chancellor for Research, Ahwaz University of Medical Sciences Effect of Simvastatin in the treatment of schizophrenia Determine the effect of Simvastatin to control negative symptoms of atypical antipsychotics in patients with schizophrenia 2012-06-21 anticipated 40 Complete https://irct.ir/trial/26134 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2 Schizophrenia. Intervention 1: In the intervention group: Simvastatin Tablets, 20 mg orally, once a day for 6 weeks. Intervention 2: Control group: Placebo tablet, 20 mg oral, once a day for 6 weeks.
public Doctor Seyed Mohammad Seyed Ghaffari Dezffooli
Ahvaz University of Medical Sciences, City University, Golestan
Ahwaz Iran (Islamic Republic of) +98 61 3336 7543 ashrafi.so@ajums.ac.ir Ahwaz Jundishapur University of Medical Sciences scientific Somayeh Ashrafi
Ahvaz University of Medical Sciences, City University, Golestan
Ahwaz Iran (Islamic Republic of) 6481958956 +98 61 3336 7543 ashrafi.so@ajums.ac.ir ; dr.ashrafi77@gmail.com Ahwaz Jundishapur University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria for this study: having a diagnosis of schizophrenia according to DSM-IV-TR؛ a PANSS total score of 50 or higher on the scale؛ the scale PANSS negative score of 15 or more of 70-18 years, during a period of at least 1 year of disease onset. Exclusion criteria for this study: patients with a history of sensitivity to statins ؛ active liver disease or increase stability and unexplained liver enzymes؛ kidney failure؛ medical condition serious؛ drug abuse or drug dependence during the previous month؛ pregnancy؛ lactation؛ there at the same time other psychiatric disorders requiring drug therapy؛ desire to commit suicide or homicide؛ possession of dementia and cognitive impairment serious؛ unrelated to schizophrenia؛ organic disease of the brain such as seizures and severe mental retardation and Parkinson's disease, Taking anti psychotic oral over the past month or long-acting injections over the past three months؛ the concomitant use of other drugs such as antidepressants or lithium؛ etc. which may be a result of treatment interfere؛ schizophrenia resistant to treatment؛ lack of response to an adequate dose and appropriate for typical anti psychotic drugs. 18 years 60 years Both F20 Schizophrenia are generally identified by distorting the basic characteristics of thinking and perception, and affects that are inappropriate or not. Clear consciousness and intellectual capacity are usually maintained although certain cognitive deficits Treatment - Drugs Treatment - Drugs In the intervention group: Simvastatin Tablets, 20 mg orally, once a day for 6 weeks Control group: Placebo tablet, 20 mg oral, once a day for 6 weeks Emotional withdrawal. Timepoint: Before the studyꓼ week thirdꓼ sixth week. Method of measurement: PANSS (Positive and Negative Symptom Scale). Social withdrawal. Timepoint: Before the experiment three weeks after the interventionꓼ six weeks after intervention. Method of measurement: PANSS (Positive And Negative Symptom Scale). Vice Chancellor for Research, Ahwaz University of Medical Sciences Approved 2012-05-12 Department of Development Research Ethics Committee of the Ahwaz University of Medical Sciences Ahvaz University of Medical Sciences, City University, Golestan Ahwaz Iran (Islamic Republic of)