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IRCT201107262751N3 IRCT 2012-03-19 Tehran University of Medical Sciences Comparison of Perforan and omega-3 on severity of premenstrual syndrome The effect of omega-3 fatty acid and Perforan on severity of symptoms in premenstrual syndrome 2011-12-31 anticipated 180 Complete https://irct.ir/trial/2585 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2 Premenstural syndrome. Intervention 1: Placebo capsules, 1000 mg, 2 times a day, orally for 3 months. Intervention 2: Perforun Capsules, 240 mg, 2 times a day, orally for 3 months. Intervention 3: Fatty acid capsules three thousand milligrams, twice daily for 3 months, orally.
public
scientific Masoomeh Kheirkhah
5th Floor of the Central Organization, Tehran University of Medical Sciences, Ghods St, Keshavarz Blvd
Tehran Iran (Islamic Republic of) +98 21 8163 3575 kheirkhah@iums.ac.ir Tehran university of medical sciences Iran (Islamic Republic of) Inclusion criteria: Regular menstrual cycles 24-35 days, 18-35 years of age and unmarried, non-psychotic mental illness, lack of physical illnesses including endocrine diseases known as non-hormonal drugs, anticoagulant, antidepressants, supplements and herbal medicine, not taking any medication for the treatment of premenstrual syndrome, No alcohol or drugs, sensitivity to the sun and sea food, relatives who died in the last 3 months, surgery in the last 3 months. Exclusion criteria: any disease endocrine disease during the study, having severe premenstrual syndrome, married during the study, Unwillingness to continue the study, If complications or allergic to a drug or other drug use, stop taking the medication for a week in regular cycles and irregular drug consumption in the second and third cycles for two days. 18 years 35 years Female F59 Unspecified behavioural syndromes associated with physiological disturbances and physical factors Treatment - Drugs Treatment - Drugs Treatment - Drugs Placebo capsules, 1000 mg, 2 times a day, orally for 3 months Perforun Capsules, 240 mg, 2 times a day, orally for 3 months Fatty acid capsules three thousand milligrams, twice daily for 3 months, orally Reduction in physical symptoms (headache, breast swelling and tenderness, back pain, abdominal pain, muscle pain, weight gain, swelling of extremities, nausea, diarrhea or constipation). Timepoint: One month, two months, three months after intervention. Method of measurement: Questionnaire. Reduction in behavioral symptoms (fatigue, lack of energy, insomnia, difficulty concentrating, increased appetite). Timepoint: One month, two months, three months after intervention. Method of measurement: Questionnaire. Reduction in mood symptoms (irritability and restlessness, anxiety and impatience, anger, depression and sadness, crying for no reason, feeling alone). Timepoint: One month, two months, three months after intervention. Method of measurement: Questionnaire. Side effects of drugs. Timepoint: Three months after the intervention. Method of measurement: Questionnaire. Tehran University of Medical Sciences Approved 2011-06-18 Tehran University of Medical Scinces 5th Floor of the Central Organization, Tehran University of Medical Sciences, Ghods St., Keshavarz Blvd Tehran Iran (Islamic Republic of)