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IRCT2017041933529N1 IRCT 2017-08-07 Vice chancellor for research, Ardabil University of Medical Sciences Acute Normovolomic Hemodilution effect on the amount of bleeding after Coronary Artery Bypass Grafting surgery in the first 48 hours postoperative Acute Normovolomic Hemodilution effect on the amount of bleeding after Coronary Artery Bypass Grafting surgery in the first 48 hours postoperative 2016-03-20 anticipated 100 Complete https://irct.ir/trial/25832 interventional Randomization: N/A, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 coronary artery bypass graft. Intervention 1: Intervention group: After induction of anesthesia in the operating room and before connecting the patient to the CPB pump, a blood unit is taken from patients in the intervention group. After completion of the surgical procedure and disconnecting of patients from the CPB pump and receiving protamine, the whole blood of patients in intervention group is retransfused. Intervention 2: Control group: No intervention will be given in the control group.
public Sahar Khajavi
Ardabil Complex Univesity, Daneshgah st., Ardabil, Ardabil Province.
Ardabil Iran (Islamic Republic of) 5619853141 +98 455512006 S.khajoo@arums.ac.ir Ardabil University Of Medical Sciences scientific Dr. Akbar Pirzadeh
Ardabil Complex Univesity, Daneshgah st., Ardabil, Ardabil Province.
Ardabil Iran (Islamic Republic of) 5615751147 +98 45 3352 2083 a.pirzadeh@arums.ac.ir Ardabil University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: No previous known history of coagulation disorders; No previous treatment with drugs used in coagulation disorders. Exclusion criteria: Anemia (hemoglobin less than 11); Massive transfusion (more than 1 blood volume or 20 packed cell); Platelet transfusion; FFP transfusion; Receiving medications such as Plavix and Transamine; Connection to the CPB pump more than 3 houres; platelet count less than 100 thousand. no limit no limit Both I25.70 unspecified coronary artery bypass graft Treatment - Other Other Intervention group: After induction of anesthesia in the operating room and before connecting the patient to the CPB pump, a blood unit is taken from patients in the intervention group. After completion of the surgical procedure and disconnecting of patients from the CPB pump and receiving protamine, the whole blood of patients in intervention group is retransfused. Control group: No intervention will be given in the control group. Amount of bleeding. Timepoint: 36 measurements in 2-hour intervals (12 times per day, in the first 3 days). Method of measurement: by graduated drains (in terms of mL). Vice chancellor for research, Ardabil University of Medical Sciences Approved 2016-06-27 Ethic Committee Of Ardabil University Of Medical Sciences Ardabil Complex Univesity, Daneshgah st., Ardabil, Ardabil Province. Ardabil Iran (Islamic Republic of)