IRCT2017040533244N1 IRCT 2017-09-20 Deputy of Research and Technology of Shiraz University of Medical Sciences Efficacy of Hydroquinone 2% cream versus Tranexamic Acid Injection Comparison of the Efficacy of Hydroquinone 2% cream versus Tranexamic Acid Injection in Treatment of Melasema 2016-12-21 anticipated 37 Complete https://irct.ir/trial/25703 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Condition 1: Melasma. Condition 2: melasma. Intervention 1: In this study, for one side of the patient, topical hydroquinone 2% is used at night. Intervention 2: On the other side, the tranexamic acid injection is used by the panel physician, with each side being randomly selected in each patient . During this study, patients will be evaluated for the incidence of side effects and recurrence of the lesion, and the rate of melasma reduction in patients will be documented both subjectively and by the device in the mucocut. In this study, the concentration of 20 mg / ml of Tranxamic Acid for topical infusion will be used; it is used by the physician in an interdermal setting at 1 cm intervals in place of melasma. 100 ml insulin is used to inject Nidal. After the local injection, the ice cream compressor will also be used. This process will be performed at intervals of 4 weeks for 3 months; then patients will follow a monthly follow up for 3 months.