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IRCT2017040433210N1 IRCT 2017-06-25 Vice Chancellor for Research of Ahvaz Jundishapur University of Medical Sciences The effect of adding dexmedetomidine to lidocaine on nerve block. Evaluation the effect of adding dexmedetomidine to lidocaine to improve quality of block and reduce the pain in patients who are candidates for fracture surgeries by supraclavicular block procedure under ultrasonic-guide. 2017-06-22 anticipated 60 Complete https://irct.ir/trial/25691 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: The study will be done randomly with Using random permutation blocks with a block size of 4 (using a table of random permutations). 3 Peripheral nerve block. Intervention 1: Control group: Injection of 30 milliliter solution containing isotonic Normal Saline plus 1 percent Lidocaine under ultrasound guidance after sensory and motor block beginning. Intervention 2: Intervention group: Injection of 30 milliliter solution containing 1 mcg per kg dexmedetomidine plus 1 percent Lidocaine under ultrasound guidance after sensory and motor block beginning.
public Dr Amir Hosein Baniahmad
Golestan boulevard
Ahvaz Iran (Islamic Republic of) 6135715794 +98 61 3222 0168 baniahmad.a@ajums.ac.ir; ahbaniahmad@gmail.com Ahvaz Jundishapur University of Medical Sciences scientific Dr Reza Akhondzade
Golestan boulevard
Ahvaz Iran (Islamic Republic of) 6135715794 +98 61 3222 0168 Rezaakh@hotmail.com Ahvaz Jundishapur University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Inclusion criteria: Patients at the age of 18-60 years with ASA physical status I or II who are candidate for forearm surgery. Exclusion criteria : History of cardiovascular and liver diseases; Sensitivity to drugs used in study; Use alfa-2 adrenergic and/or analgesic before the surgery; Patients with neurological and/or psychological disorders. no limit no limit Both Treatment - Drugs Treatment - Drugs Control group: Injection of 30 milliliter solution containing isotonic Normal Saline plus 1 percent Lidocaine under ultrasound guidance after sensory and motor block beginning. Intervention group: Injection of 30 milliliter solution containing 1 mcg per kg dexmedetomidine plus 1 percent Lidocaine under ultrasound guidance after sensory and motor block beginning. Onset of sensory block. Timepoint: 5-10-15 -30 minute intervals after injection. Method of measurement: Physical Examination by Physician (Pinprick test). Onset of motor block. Timepoint: 5, 10, 15 and 30 minutes after injection. Method of measurement: Physical Examination by Physician (modified bromage scale). Duration of sensory block. Timepoint: Untile patients analgesic request. Method of measurement: Physical Examination by Physician. Duration of motor block. Timepoint: Untile start movement around median, radial, and ulnar nerves. Method of measurement: Physical Examination by Physician. The time of first Analgesic Request. Timepoint: One hour intervals untile first 24 hours. Method of measurement: Patient's file. Analgesic received in 24 hours. Timepoint: 24 hours after surgery. Method of measurement: Patient's documents. Heart Rate per minute. Timepoint: Before block (base line) then every 5 minutes after block, then every 5 minutes after starting surgery till end of surgery and then every 15 minute till Departure time from recovery. Method of measurement: Cardiac Monitoring Device. Arterial Oxygen Saturation. Timepoint: Before block (base line) then every 5 minutes after block, then every 5 minutes after starting surgery till end of surgery and then every 15 minute till Departure time from recovery. Method of measurement: Continious Pulse Oximetry. Mean Arterial Pressure. Timepoint: Before block (base line) then every 5 minutes after block, then every 5 minutes after starting surgery till end of surgery and then every 15 minute till Departure time from recovery. Method of measurement: By non-invasive Manometer device(millimeter Hg). Vice Chancellor for Research of Ahvaz Jundishapur University of Medical Sciences Approved 2017-04-15 Ethics Committee of Ahvaz Jundishapur University of Medical Sciences Golestan boulevard Ahvaz Iran (Islamic Republic of)