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IRCT201609102709N38 IRCT 2016-10-09 Vice chancellor for research, Iran University of Medical Sciences Effect of Vitamin D supplementation on regulation of hormones secreted, Anti Oxidant Enzyme and Apo lipoproteins in obese and overweight people undergoing low calorie diet Effect of Vitamin D supplementation on serum DHEA, Insulin, apo B100, apo A1,PON1 and FFA in obese and overwight people undergoing low calorie diet 2016-10-22 anticipated 70 Complete https://irct.ir/trial/2549 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2-3 Obesity And Overweight. Intervention 1: Intervention groups: receive 50000 IU vit D once in first week as a blues and 2000 IU vit D per day from second week and 0.5 to 1 kg per week weight lose for 8 weeks in obese and over weight people undergoing low callorie diet. . Intervention 2: control group: receive placebo of vitamin D (edible paraffin) every week for 8 weeks in obese and over weight people undergoing low callorie diet.
public Dr Farzad Shidfar
Faculty of Nutrition, School of Public Health, Iran University of Medical Sciences, next to the Milad hospital, the intersection of Sheikh Fazlallah and Shahid Chamran, Shahid Hemmat expressway
Tehran Iran (Islamic Republic of) +98 21 8670 4711 shidfar.f@iums.ac.ir Iran University of Medical Sciences, School of Public Health scientific Dr Farzad Shidfar
Faculty of Nutrition, School of Public Health, Iran University of Medical Sciences, next to the Milad hospital, the intersection of Sheikh Fazlallah and Shahid Chamran, Shahid Hemmat expressway
Tehran Iran (Islamic Republic of) +98 21 8670 4711 shidfar.f@iums.ac.ir Iran University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: age of 20-50; BMI= 25-40; don’t taking the glucose and lipid- lowering drugs; vitamin D deficiency; interesting in participation in research; without any metabolic disease; CHD; diabetes; without autoimmune disease; cancer; without infection disease in research; no smoking; no alcoholism; without immune system suppressor drugs 6 mounts before research; no menstrual bleeding; without any diet 3 mounts before research; no consumption vit D and antioxidant supplementation and multivitamin mineral during research; without use of medication affecting Vitamin D metabolism; without use of tanning bed during the study and 3 months before study initiation; without renal and hepatic diseases; women without polycystic ovary syndrome exclusion criteria: metabolic; CHD; autoimmune disease and cancer; infection disease in research; smoking; alcoholism; use of immune system suppressor drugs 6 mounts before research; menstrual bleeding; diet 3 mounts before research; consumption vit D supplementation and multivitamin mineral during research; use of medication affecting Vitamin D metabolism; use of tanning bed during the study and 3 months before study initiation; Having renal and hepatic diseases; women with polycystic ovary syndrome; no interesting for participation 20 years 50 years Both E66.0 Obesity due to excess calories Prevention Placebo Intervention groups: receive 50000 IU vit D once in first week as a blues and 2000 IU vit D per day from second week and 0.5 to 1 kg per week weight lose for 8 weeks in obese and over weight people undergoing low callorie diet. . control group: receive placebo of vitamin D (edible paraffin) every week for 8 weeks in obese and over weight people undergoing low callorie diet. PON 1, FFA. Timepoint: Before and after intervention. Method of measurement: ELIZA. Apo B100, apo A1. Timepoint: Before and after intervention. Method of measurement: ELIZA. DHEA, Insulin. Timepoint: Before and after intervention. Method of measurement: ELIZA. Vitamin D. Timepoint: Before and after intervention. Method of measurement: ELIZA. Fat Percent. Timepoint: Before and after intervention. Method of measurement: BIA method. BMI. Timepoint: Before and after intervention. Method of measurement: Formula. Waist circumference. Timepoint: Before and after intervention. Method of measurement: Meter. Systolic blood pressure. Timepoint: Before and after intervention. Method of measurement: manometer. Diastolic blood pressure. Timepoint: Before and after intervention. Method of measurement: manometer. Nutritional status. Timepoint: Before and after intervention. Method of measurement: Measurement of energy and nutrients intake using 24-hour dietary recall method and anthropometric measurement using scale and stadiometer. Exposure of sunlight. Timepoint: Before and after intervention. Method of measurement: Exposure of sinlights questionnaire. Phisical Activity. Timepoint: Before and after intervention. Method of measurement: International phisical activity questionnair ( IPAQ). Vice chancellor for research, Iran University of Medical Sciences Approved 2016-09-14 Ethics Committee of Iran University of Medical Sciences Iran University of Medical Sciences, next to the Milad hospital, the intersection of Sheikh Fazlallah and Shahid Chamran, Hemmat expressway Tehran Iran (Islamic Republic of)