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IRCT201301182709N27 IRCT 2013-03-24 Tehran University of Medical Sciences and Health services The effect of iron and omega-3 on coronary heart disease The effect of supplementation with iron alone and combined with the docosahexaenoic acid and changes in serum lipid profile on risk of Coronary- heart disease via measuring paraoxonase 1, hs-CRP and the ApoB / ApoA1 ratio in women with iron deficiency anemia 2013-04-04 anticipated 80 Complete https://irct.ir/trial/2540 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive. N/A Condition 1: Iron deficiency anaemia. Condition 2: Iron deficiency anaemia. Intervention 1: Group df or intervention: Patients with iron deficiency anemia that is based on sharing random daily receive capsule supplement DHA-containing (465 mg DHA + 63 mg EPA) + a tablet into sulfate containing 50 mg elemental iron for 12 weeks . Intervention 2: Group or the control pf: People with iron-deficiency anemia that is based on sharing a random day a number of placebo capsules containing 500 mg of corn oil + a tablet of sulfate contains 50 mg of elemental iron for 12 weeks to receive .
public Samira Amani
not the bottom left deadlocked belt last, Alley Rajai martyr, Tehran St, Ghaemshahr, Mazandaran, Iran
Ghaemshahr Iran (Islamic Republic of) +1 232370630 s.amani5n@gmail.com Tehran University of Medical Therapy scientific F. Shidfar doctor
Tehran University of Medical Sciences, Department of Nutrition and Diet, Tehran
Tehran Iran (Islamic Republic of) +98 21 8877 9118 f-shidfar@tums.ac.ir Tehran University of Medical Sciences and Health Services Iran (Islamic Republic of) Inclusion criteria: • Serum ferritin less than 12 ϻ g / l and serum iron of 60 mcg/100ml • Women in the range of 15 to 45 years of age • regular menstrual cycles • willingness to cooperate and fill the criteria of informed consent form to the project exclusion criteria: • smoking tobacco or alcohol • iron supplements, multivitamins and antioxidants in the last three months • the use of lipid-lowering drugs, oral contraceptives • the use of oral contraceptives • parasitic infections (those who have been diagnosed positive stool test will be excluded.) • thalassemia disease • kidney disease, liver disease, diabetes • local or systemic infection or inflammatory disease • history of ulcer disease or gastrointestinal bleeding or fibroids •malabsorption such as celiac sprue or steatorrhea • Any type of blood transfusion in the last 2 months of • pregnancy or lactation • not wanting to continue working • inadequate compliance supplement (compliance less than 80%) • change in diet or physical activity for any reason 15 years 45 years Female D50.9 D50.8 Iron deficiency anaemia, unspecified Other iron deficiency anaemias Treatment - Drugs Placebo Group df or intervention: Patients with iron deficiency anemia that is based on sharing random daily receive capsule supplement DHA-containing (465 mg DHA + 63 mg EPA) + a tablet into sulfate containing 50 mg elemental iron for 12 weeks . Group or the control pf: People with iron-deficiency anemia that is based on sharing a random day a number of placebo capsules containing 500 mg of corn oil + a tablet of sulfate contains 50 mg of elemental iron for 12 weeks to receive . Fasting serum ferritin. Timepoint: before the experiment.12 weeks after intervention. Method of measurement: According ϻ g / l Lyazvn method. Paraoxonase 1 activity. Timepoint: before the experiment.12 weeks after intervention. Method of measurement: By U / L spectrophotometry. Fasting serum ApoB levels. Timepoint: before the experiment.12 weeks after intervention. Method of measurement: Based on Mg / dl Turbydymtry method. Fasting serum concentrations of ApoA1. Timepoint: before the experiment.12 weeks after intervention. Method of measurement: Based on Mg / dl Turbydymtry method. Fasting concentrations of serum HS-CRP. Timepoint: before the experiment.12 weeks after intervention. Method of measurement: Based on Mg / l immunohistochemical method Flumtryk. Fasting serum iron. Timepoint: before the experiment.12 weeks after intervention. Method of measurement: According ϻ g / dl spectrophotometry. Body mass index. Timepoint: Before the experiment, 12 weeks after intervention. Method of measurement: Kg/m2 calculated based on the height and weight. Age. Timepoint: Before the experiment, 12 weeks after intervention. Method of measurement: In terms of the question. Energy intake. Timepoint: Before the experiment, 12 weeks after intervention. Method of measurement: Terms (kcal / day) over a 24-hour dietary questionnaire. Carbohydrate intake. Timepoint: Before the experiment, 12 weeks after intervention. Method of measurement: Terms (g/day) over a 24-hour dietary questionnaire. Protein intake. Timepoint: Before the experiment, 12 weeks after intervention. Method of measurement: Terms (g/day) over a 24-hour dietary questionnaire. Fat intake. Timepoint: Before the experiment, 12 weeks after intervention. Method of measurement: Terms (g/day) over a 24-hour dietary questionnaire. Fiber intake. Timepoint: Before the experiment, 12 weeks after intervention. Method of measurement: Terms (g/day) over a 24-hour dietary questionnaire. Vitamin A. Timepoint: Before the experiment, 12 weeks after intervention. Method of measurement: Terms (mg/day) over a 24-hour dietary questionnaire. Vitamin C. Timepoint: Before the experiment, 12 weeks after intervention. Method of measurement: Terms (mg/day) over a 24-hour dietary questionnaire. Vitamin E. Timepoint: Before the experiment, 12 weeks after intervention. Method of measurement: Terms (mg/day) over a 24-hour dietary questionnaire. Betacarotene. Timepoint: Before the experiment, 12 weeks after intervention. Method of measurement: Terms (mg/day) over a 24-hour dietary questionnaire. Iron. Timepoint: Before the experiment, 12 weeks after intervention. Method of measurement: Terms (mg/day) over a 24-hour dietary questionnaire. Zinc. Timepoint: Before the experiment, 12 weeks after intervention. Method of measurement: Terms (mg/day) over a 24-hour dietary questionnaire. Selenium. Timepoint: Before the experiment, 12 weeks after intervention. Method of measurement: Terms (mg/day) over a 24-hour dietary questionnaire. Copper. Timepoint: Before the experiment, 12 weeks after intervention. Method of measurement: Terms (mg/day) over a 24-hour dietary questionnaire. Sodium. Timepoint: Before the experiment, 12 weeks after intervention. Method of measurement: Terms (mg/day) over a 24-hour dietary questionnaire. Potassium. Timepoint: Before the experiment, 12 weeks after intervention. Method of measurement: Terms (mg/day) over a 24-hour dietary questionnaire. Kind of fat. Timepoint: Before the experiment, 12 weeks after intervention. Method of measurement: Terms (mg/day) over a 24-hour dietary questionnaire. Level of physical activity. Timepoint: Before the experiment, 12 weeks after intervention. Method of measurement: In terms of intensity (light, medium and heavy) information through a questionnaire. Tehran University of Medical Sciences and Health services Approved 2013-02-18 Tehran University of Medical Sciences & Health Services Tehran, Department of Nutrition and Diet, Tehran University of Medical Sciences Tehran Iran (Islamic Republic of)