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IRCT2017013132319N1 IRCT 2017-05-01 Shiraz University of Medical Sciences The effect of topical semisolid formulation of metformin on severity and number of skin lesions in acne patients. The effect of topical semisolid formulation of metformin on acne. The comparison of therapeutic effect on severity and number of skin lesions, between metformin semisolid formulation and placebo, in patients with mild to moderate Acne vulgaris. 2017-05-22 anticipated 20 Complete https://irct.ir/trial/25214 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A Acne vulgaris. Intervention 1: The case group, will receive semisolid formulation of metformin, twice a day, for two months and Azithromycin 250mg caplet will be used every other day. Intervention 2: The control group will receive the base of semisolid formulation, the preparation will be administrated topically , two times in a day and for two months and Azithromycin 250mg caplet will be used every other day.
public Dr Nasrin Saki
Imam Hossein square-Shahid Faghihi Hospital
Shiraz Iran (Islamic Republic of) 7134844119 +98 71 3235 1090 nasrinsa85@yahoo.com Shahid Faghihi Skin and Dermatology Clinic- Shiraz-Iran scientific Dr Amir Azadi
Karafarin St- School of Pharmacy
Shiraz Iran (Islamic Republic of) 7146864685 +98 71 3242 4127 aazadi@sums.ac.ir Shiraz University of Medical Sciences-Faculty of Pharmacy Iran (Islamic Republic of) Inclusion criteria:Patients with mild to moderate acne, defined as a score of 1 to 30 on the global acne grading system (GAGS) scale, who did not get any treatment before, or were not satisfied with their previous acne therapies, will be participated in the study after giving written informed consent. Exclusion criteria: Patients will be excluded if they are diabetic or have an uncontrolled systemic disease; have received topical anti acne therapy two months before or during the study or any systemic therapy, 30 days before or during the study; were known to be allergic or sensitive to any of the study medications or their components; have a skin disease that might interfere with the diagnosis or evaluation of their skin lesions; pregnant women and lactating ones. no limit no limit Both L70.0 Acne vulgaris Treatment - Drugs Placebo The case group, will receive semisolid formulation of metformin, twice a day, for two months and Azithromycin 250mg caplet will be used every other day. The control group will receive the base of semisolid formulation, the preparation will be administrated topically , two times in a day and for two months and Azithromycin 250mg caplet will be used every other day. Skin lesions. Timepoint: 0 , 4 , 8 weeks. Method of measurement: Observation. Patients satisfaction. Timepoint: 0,4,8 weeks. Method of measurement: determined by a 10 point scale ranging. Shiraz University of Medical Sciences Approved 2017-04-17 Shiraz University of Medical Sciences Shiraz- Imam Hossein square-Zand Avenue-The Central Building of Shiraz University of Medical Sciences-7th floor Shiraz Iran (Islamic Republic of)