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IRCT138706111157N1 IRCT 2009-04-11 Jahad Daneshgahi The efficacy of Rheum ribes L stalk extract on lipid profile in hypercholesterolemic type II diabetic patients. A randomized, double-blind, placebo-controlled, clinical trial. The efficacy of Rheum ribes L stalk extract on lipid profile in hypercholesterolemic type II diabetic patients a randomized, double-blind, placebo-controlled, clinical trial. 2006-05-21 anticipated 36 Complete https://irct.ir/trial/252 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 3 Hypercholesterolemia. Intervention 1: Placebo capsule 400 mg 3 times a day treatment orally for one month. Intervention 2: Rheum Ribes 400 mg capsule 3 times a day treatments orally for one month.
public Hassan Fallah Huseini
Jahad daneshgahi research society, Tehran-Qazvin Highway
Karaj Iran (Islamic Republic of) 31375369 +98 261476401019 fallah@imp.ac.ir huseini_fallah@yahoo.com Institute of Medicinal Plants, ACECR scientific Hassan Fallah Huseini
Jahad-Daneshgahi research society (ACECR) Tehran-Qazvin Highway,
karaj Iran (Islamic Republic of) 31375369 +98 261476401019 fallah@imp.ac.ir huseini_fallah@yahoo.com Institute of Medicinal Plants Iran (Islamic Republic of) Inclusion criteria: Age between 40 to 60 years, serum cholesterol above 100 mg/dl, confirmed type II diabetes at least for two years with fasting blood glucose above 150-250 mg/dl taking Metformin or Glibenclamid, HbA1c 7.5-10%, not taking any antihypercholesterolmic drug during past month, signing the written informed consent. Exclusion criteria: Insulin therapy, infectious diseases, severe kidney, liver, heart and pulmonary diseases, hypersensitivity to any drug, foot ulcer or gangrene, major depressive disorder, previous myocardial infarction, active cancer or previous cancer during past 5 years, history of alcohol consumption or cigarette smoking, pregnancy, breast feeding. 40 years 60 years Both E78 Disorders of lipoprotein metabolism and other lipidaemias Treatment - Drugs Placebo capsule 400 mg 3 times a day treatment orally for one month Rheum Ribes 400 mg capsule 3 times a day treatments orally for one month LDL cholesterol. Timepoint: Baseline and after one month. Method of measurement: The fasting serum LDL cholesterol concentration determined in blood sample by calculating HDL and total cholesterol level. Blood glucose. Timepoint: Baseline and after one month. Method of measurement: The fasting serum glucose concentration determined in blood sample by glucose oxidase method. Total cholesterol. Timepoint: Baseline and after one month. Method of measurement: The fasting serum total cholesterol level in blood sample by enzymatic oxidase method. HDL. Timepoint: Baseline and after one month. Method of measurement: The fasting blood HDL level in blood sample by CDC designated comparison method. Triglyceride. Timepoint: Baseline and after one month. Method of measurement: The fasting blood Triglyceride level in blood sample by enzymatic oxidase method. SGOT. Timepoint: Baseline and after one month. Method of measurement: The fasting blood SGOT level in blood sample by DGKG enzymatic method. SGPT. Timepoint: Baseline and after one month. Method of measurement: The fasting blood SGPT level by DGKG enzymatic method. Creatinine. Timepoint: Baseline and after one month. Method of measurement: The fasting blood Creatinine level in blood sample by JAPH enzymatic method. Endocrinology & Metabolism Research Center Jahad Daneshgahi Endocrinology & Metabolism Research Center Approved 2005-11-10 Endocrinology & Metabolism Research Center, Tehran University of Medical Sciences Endocrinology & Metabolism Research Center, Tehran University of Medical Sciences Tehran IR IRAN Tehran Iran (Islamic Republic of)