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IRCT20170120032069N5 IRCT 2019-11-10 Tehran University of Medical Sciences Desmopressin effects on bleeding after functional endoscopic sinus surgery on patients with chronic rhinosinusitis with and without polyposis desmopressin effects on bleeding after functional endoscopic sinus surgery on patients with chronic rhinosinusitis with and without polyposis 2019-03-21 anticipated 19 Complete https://irct.ir/trial/25077 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: Patients eligible for inclusion in the study are interviewed first and explained to the project, and, if satisfied, to participate in the study, the patients will receive written consent to be included in the plan and informed of them. They will be randomly assigned to either group. The blocking method will be used to select patients in one of the two intervention and control arms so that they are selected using the random numbers table of the 4 blocks and then the items will be selected and introduced with time review. It should be noted that in this study, the patients, the team of surgeons, the anesthetic team and the operating room team did not know the control or intervention of the patients, and the intervention group and the placebo group were both surgically operated by a professor, and for both groups 100 cc My head is ready to be used, which the surgical team and the data analyst do not know about its nature, Blinding description: In this study, the patients, the team of surgeons, the anesthetic team and the operating room team were unaware of the control or intervention of the patients, and the intervention group and the placebo group were both surgically treated by a professor. 3 chronic rhinosinositis with and without polyposis. Intervention 1: Intervention group: Intervention group: 100mg normal saline containing 0.1μgr / kg desmopressin will be injected 1 min before surgery in case group. If the surgeon is dissatisfied from the operation field, a second dose of the drug is injected 30 minutes after surgery. Intervention 2: Control group: In this group, 100 ml of normal saline is injected 30 minutes before surgery. Yes - There is a plan to make this available What will be shared: Demographic information and information of samter's Triad and Land McKay Score and the results of some tests are available. When: Access is available 2 years after the final results are published To whom: The results are accessible to researchers working in academic institutions and universities. Conditions: To access the data, they must specify the type of data and specify the type of data to use. Where to obtain: To receive the type of information, they can email the following email jawadhosseini.md@gmail.com How to obtain: After submitting the request by email, their request will be reviewed by the research team and Up to 6 months after the request is submitted, their request will be sent to their email address. Comments:
public Jawad Hosseini
Darvaze Dolat, Saadi st, Engelab st
Tehran Iran (Islamic Republic of) 1145765111 +98 21 6670 6106 jawadhosseini.md@gmail.com Tehran University of Medical Sciences scientific Jawad Hosseini
north Sadi Ave., Enqelab Ave.
Tehran Iran (Islamic Republic of) 1145765111 +98 21 6670 3037 jawadhosseini.md@gmail.com Tehran University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Patients with chronic rhinosinusitis in the age group of 15-60 years old No heart disease without Background coagulation disorders Without high blood pressure No history of previous FESS surgery 15 years 60 years Both If patients are not satisfied with entering the project chronic Rh chronic Rhinosinositis, polyposis, Desmopressin, FESS Treatment - Drugs Placebo Intervention group: Intervention group: 100mg normal saline containing 0.1μgr / kg desmopressin will be injected 1 min before surgery in case group. If the surgeon is dissatisfied from the operation field, a second dose of the drug is injected 30 minutes after surgery. Control group: In this group, 100 ml of normal saline is injected 30 minutes before surgery. Reduce bleeding during FESS surgery - better view of surgeon on operating field -- Reduce the time of surgery. Timepoint: Measuring the amount of bleeding at the end of surgery .... Measuring surgeon satisfaction at the end of surgery .... Measuring the time of surgery at the end of surgery. Method of measurement: Calibrated container to measure the amount of bleeding. A numerical questionnaire is used to measure the surgeon's satisfaction .measure the time of operation by clock. Reduce the need for postoperative blood transfusions .... Reduce the need for intraoperative anesthesia. Timepoint: Both outcomes are measured at the end of surgery. Method of measurement: The rate of hemoglobin loss at the end of surgery and the amount of anesthetic drugs used during surgery. Tehran University of Medical Sciences Approved 2019-06-22 Vice-Chancellor in Research Affairs- Tehran University of Medical Amiralam hospitla, north sadi av. Enqelab av. تهران Tehran Iran (Islamic Republic of)