IRCT2017010831824N1 IRCT 2017-11-06 Vice chancellor for research Zanjan University of Medical Sciences The impact of sedation protocol on some clinical outcomes of mechanically ventilated patients The impact of sedation protocol using Richmond Agitation-Sedation Scale (RASS) on some clinical outcomes of mechanically ventilated patients in the Intensive Care Unit (ICU): A Clinical Trial 2017-01-20 anticipated 90 Complete https://irct.ir/trial/24944 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Other design features: Randomization: All the eligible patients will be included in the study from Feb 2017 to May 2017 (The Poisson simple random sampling). The first five patients will be allocated to the intervention (head) or control (tail) group, and the second five patients will be allocated to the other group (tails) using tossing a coin. 3 Sedation. Intervention 1: In the proposed protocol, the sedation level of patients will be assessed and recorded using RASS Scale each hour, at the same time of assessment of patients' vital signs by nurses. No particular intervention will be needed if the score is less than -2. If the patient’s Richmond score is between 1 and -1, sedation drugs will be infused just before invasive procedures. However, the patient will receive the appropriate nursing interventions (non-drug interventions) such as repositioning, reducing the endotracheal tube pressure on mouth or nose, reducing environmental noise, etc. if their sedation level score is more than +2. If the patients are sedated, the sedation level will be checked hourly; otherwise, the RASS Scale will be applied and the sedative drugs will be administered according to the patient’s medication order. Intervention 2: The control group will receive the routine treatment and sedation according to the patients' physiological reactions and nurses' clinical judgment to control pain.