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IRCT138808182685N1 IRCT 2009-12-05 Vice-chancellor for Research, Kurdistan University of Medical Sciences The effect of low-dose oral Theophylline drug on active c serum protein level in patients with stable chronic obstructive pulmonary disease The effect of low-dose oral Theophylline on serum HS-CRP in patients with stable COPD 2008-12-05 anticipated 50 Complete https://irct.ir/trial/2488 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 3 Chronic obstructive pulmonary disease. Intervention 1: Placebo with dose of 200 mg every 12 hours for one month. Intervention 2: Theophylline tablets, 200 mg every 12 hours for one month.
public Dr. Naseh Sigari
Gheryashan Street, Tohid Hospital, Pulmonary subspecialty ward
Sanandaj Iran (Islamic Republic of) +98 87 1328 6113 naseh46@muk.ac.ir Kurdistan University of Medical Sciences scientific Dr. Naseh Sigari
Pulmonary subspecialty ward, Tohid Hospital, Gheryashan Street,
Sanandaj Iran (Islamic Republic of) +98 87 1328 6113 naseh46@muk.ac.ir naseh46@yahoo.com Kurdistan University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Inclusion criteria: stable COPD (no exacerbation in the past two months), FEV1/FVC ratio less than 70%. Exclusion criteria: no smoking history, FEV1 increased more than 200 cc or 12% after administration of 400 micrograms spray Salbutamol in spirometry, clinical or radiographic evidence of pneumonia, history of infectious disease such as tuberculosis, recent respiratory tract infections, bronchiectasis, acute or chronic diarrhea, rheumatoid arthritis, degenerative disease of large joint, vasculitis, and the possibility of malignancy based on history and examination and Theophylline use during a month prior to the enrollment no limit no limit Both J40, J43 chronic Bronchitis, Emphysema with FEV1<70 Placebo Treatment - Drugs Placebo with dose of 200 mg every 12 hours for one month Theophylline tablets, 200 mg every 12 hours for one month HS-CRP serum levels. Timepoint: Before and after intervention. Method of measurement: ELISA. Vice-chancellor for Research, Kurdistan University of Medical Sciences Approved 2008-12-22 Ethics committee of Kurdistan University of Medical Sciences Vice-chancellor for Research, Kurdistan University of Medical Sciences, Pasdaran Street, Sanandaj Iran (Islamic Republic of)