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IRCT20161219031463N2 IRCT 2019-03-09 Mashhad University of Medical Sciences Improving effects of olibanum on learning and memory Study of adding Boswellia serrata resin to therapy of patients with mild to moderate Alzheimer's disease on cognitive status compared with placebo 2018-10-09 anticipated 30 Complete https://irct.ir/trial/24743 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization was done individually, block and using the website www.Randomization.com with 6 subjects per block. This was done by an indipendent researcher and was given to the capsule deliverer by naming the unknown letters that the person did not know the original name of the capsules named in letters, Blinding description: Groups as paticpants, clinical care givers, outcome evaluators and data analyzer are not aware of the presence of samples in the control group of the placebo or the study group. So that the duty of dividing the patients into two groups was performed by the person who was not dependent on the study, and the distribution of the drug and placebo was done by the same person, and until the end of the study, information about the grouping of patients was reserved by this person. 2 Alzheimer's disease. Intervention 1: Intervention group: A capsule containing 750 mg of Olibuma resin is taken orally three times per day for 12 weeks. Capsules are provided by the Pharmacy Department of Herbal Drugs at Imam Reza Pharmacy in Mashhad. Intervention 2: Control group: The placebo is used in the form of capsules are apparently similar to the study drug , which contains 500 mg of starch powder three times a day for 12 weeks orally. Capsules are provided by the pharmacy department of Herbal Drugs at Imam Reza Pharmacy in Mashhad. Yes - There is a plan to make this available What will be shared: Demographic data, MMSE and CDR tests' scores When: Start the access period 6 months after Releasing the results To whom: Researchers working in academic and scientific institutions Conditions: For use in complementary studies including repeat study with higher sample size Where to obtain: Dr Hamid Reza Sadeghnia, Mashhad Faculty of Medicine, Department of Pharmacology Email: Sadeghniahr@mums.ac.ir Fax: +98 51 3882 8567 Address: Pharmacology Department, Faculty of Medicine, Inside campus college, Azadi square Postal code: 91388-13944 How to obtain: Submit a formal and written request from the Research, Academic and Scientific Institute at the address above Comments: No comments
public Hamid Reza Sadeghnia
Pharmacology Department, Faculty of Medicine, Inside campus college, Azadi square
Mashhad Iran (Islamic Republic of) 91388-13944 +98 51 3800 2257 Sadeghniahr@mums.ac.ir Mashhad University of Medical Sciences scientific Hami Reza Sadeghnia
Pharmacology Department, Faculty of Medicine, Inside campus college, Azadi square
Mashhad Iran (Islamic Republic of) 91388-13944 +98 51 3800 2257 Sadeghniahr@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Patients with mild to moderate Alzheimer's disease based on the score of the MMSE test between 10-23 55 years 82 years Both Diagnosis of Alzheimer's disease less than 6 months before entering the study Using cholinesterase inhibitors and / or memantine less than 90 days before entering the study or discontinuing them less than 90 days before entering the study Use of other drugs and substances such as ginkgo biloba or vitamin E that affect cognitive status less than 60 days before entering the study or discontinued less than 90 days before entering the study. Vascular dementia, thyroid disease, vitamin B12 deficiency, anemia, Lewy body dementia, liver function disorders, brain tumors, ischemic cerebrovascular accidents F00 Dementia in Alzheimer disease Treatment - Drugs Placebo Intervention group: A capsule containing 750 mg of Olibuma resin is taken orally three times per day for 12 weeks. Capsules are provided by the Pharmacy Department of Herbal Drugs at Imam Reza Pharmacy in Mashhad Control group: The placebo is used in the form of capsules are apparently similar to the study drug , which contains 500 mg of starch powder three times a day for 12 weeks orally. Capsules are provided by the pharmacy department of Herbal Drugs at Imam Reza Pharmacy in Mashhad Cognitive status. Timepoint: Study of cognitive status at the beginning of the study (before the intervention) and 12 weeks after the start of use of capsule containing Olibanum resin or placebo. Method of measurement: Using MMSE and CDR tests. Mashhad University of Medical Sciences Approved 2016-12-18 The Ethics Committee of Mashhad University of Medical Sciences Ghershi building, Daneshgah Ave. Mashhad Razavi Khorasan Iran (Islamic Republic of)