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IRCT2016101630327N1 IRCT 2016-11-30 Kermanshah University of Medical Sciences The effect of an anesthetic combination drug containing Propofol-Remifentanil-Daxmedetomidine on blood pressure and heart rate and postoperative complications in spine and spinal cord surgery. Comparison the effect of combination of Propofol-Remifentanil-Dexmedetomidine on hemodynamic parameters and postoperative complications in spine and spinal cord surgery. 2016-03-20 anticipated 60 Complete https://irct.ir/trial/24131 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. N/A effect of drug. Intervention 1: 15 minutes before time of induction, Daxmedetomidine 0.6mic / kg / h and remifentanil 1mic/Kg/min are infused, at the time of induction Propofol 1-2.5 mg/Kg and neuromuscular blocking drug (Cisatracurium) 0.15 mg/Kg are injected and patient are intubated. Intervention 2: 15 minutes before time of induction, Remifentanil 1mic/Kg/min is infused, at the time of induction Propofol 1-2.5 mg/Kg and neuromuscular blocking drug (Cisatracurium) 0.15 mg/Kg are injected and patient are intubated.
public Mohammad Javad Moradi
Beheshti Blvd., Kermanshah University of Medical Sciences headquarters
Kermanshah Iran (Islamic Republic of) 6714415333 +98 83 3427 6308 m_javad1550@yahoo.com Kermanshah University of Medical Sciences scientific Khosro Farhadi
Kermanshah University of Medical Sciences
Kermanshah Iran (Islamic Republic of) 6714415333 +98 83 3427 6308 kh_farhady@yahoo.com Kermanshah University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: patients undergoing spine surgery and spinal referring to Imam Reza Kermanshah American Society of Anesthesiologists class (I-II). Exclusion criteria: patients with a history of severe systemic disease; body mass index greater than 30; patients with a history of high blood pressure (Blood Pressure greater than 140/90); severe respiratory diseases does not control; symptomatic heart disease; diabetic patients; consumers beta-blocker drugs; drug-addicted patients; patients with more than one laryngoscopy; the extreme sensitivity to drugs personality disorder; patients with more than 750 cc of blood during surgery. 20 years 60 years Both T88.7 Unspecified adverse effect of drug or medicament Prevention Prevention 15 minutes before time of induction, Daxmedetomidine 0.6mic / kg / h and remifentanil 1mic/Kg/min are infused, at the time of induction Propofol 1-2.5 mg/Kg and neuromuscular blocking drug (Cisatracurium) 0.15 mg/Kg are injected and patient are intubated. 15 minutes before time of induction, Remifentanil 1mic/Kg/min is infused, at the time of induction Propofol 1-2.5 mg/Kg and neuromuscular blocking drug (Cisatracurium) 0.15 mg/Kg are injected and patient are intubated. Blood Pressure. Timepoint: 15 minutes before induction, intubation time, two minutes afte intubation, time of change position, and two minutes after the change of position, intraoperative period in minutes of 15,30,45,90, time of repositioning, two minutes after switching position. and before extubation, two, thirty and sixty minutes after extubation. Method of measurement: in mmHg using mercuric manometer. Heart Rate. Timepoint: 15 minutes before induction, intubation time, two minutes afte intubation, time of change position, and two minutes after the change of position, intraoperative period in minutes of 15,30,45,90, time of repositioning, two minutes after switching position. and before extubation, two, thirty and sixty minutes after extubation. Method of measurement: number of heart rate in one minute. Shivering. Timepoint: Postoperative. Method of measurement: Standard questionnaire. Nausea. Timepoint: Postoperative. Method of measurement: VAS. Vomiting. Timepoint: Postoperative. Method of measurement: VAS. Kermanshah University of Medical Sciences Approved 2016-06-08 Kermanshah University of Medical Sciences Ethics Committee Beheshti Blvd., Kermanshah University of Medical Sciences headquarters Kermanshah Iran (Islamic Republic of)