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IRCT201310221155N17 IRCT 2014-09-03 Guilan Univercity of Medical Sciences The effect of gemifloxacin in treatment of H.pylori infection Comparision of two quadriple regimen amoxicillin, bismuth subsalicylate, pantoprazole, clarythromycin and amoxicillin, bismuth subsalicylate, pantoprazole, gemifloxacin in eradication of H.pylori infection 2013-10-23 anticipated 182 Complete https://irct.ir/trial/241 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 3 Dyspepsia. Intervention 1: Control group take cap amoxicillin 500 miligram two numbers every 12 hours, tab bismuth subsalicylate 120 miligram two numbers every 12 hours, tab pantoprazole 20 miligram one number daily, tab clarythromycin 500 miligram one number every 12 hours for 10 days period. Intervention 2: Intervention group take cap amoxicillin 500 miligram two numbers every 12 hours, tab bismuth subsalicylate 120 miligram two numbers every 12 hours, tab pantoprazole 20 miligram one number daily, tab gemifloxacin 320 miligram one number daily for 10 days period.
public Farahnaz Joukar
Sardar Jangal Ave, Gastrointestinal and Liver Diseases Research Center, Razi hospital, Rasht
Rasht Iran (Islamic Republic of) 955655-41448 +98 13 1553 5116 info@gldrc.org Gastrointestinal and Liver Diseases Research Center scientific Dr.Fariborz Mansour-Ghanei
Sardar Jangal Ave, Gastrointestinal and Liver Diseases Research Center, Razi Hospital, Rasht, Iran
Rasht Iran (Islamic Republic of) 95655-41448 +98 13 1553 5116 info@gldrc.org Gastrointestinal and Liver Diseases Research Center Iran (Islamic Republic of) Inclusion criteria: New cases of H.pylori infection; patients between 18 to 80 years old Exclusion criteria: The pregnant and brest feeding women; gastric and esophagial malignancies; pylor stenosis; iiver cirrhosis; opium addicts; hypersensitivity to amoxicillin; bismuth subsalicylate; pantoprazole; clarythromycin; gemifloxacin; using cholestyramine; renal failure; history of sizzure; favism and hematologic disorders; incomplete treatment (under 80%); consent to continue treatment; history of H.pylori treatment 18 years 80 years Both k30 Dyspepsia Treatment - Drugs Treatment - Drugs Control group take cap amoxicillin 500 miligram two numbers every 12 hours, tab bismuth subsalicylate 120 miligram two numbers every 12 hours, tab pantoprazole 20 miligram one number daily, tab clarythromycin 500 miligram one number every 12 hours for 10 days period Intervention group take cap amoxicillin 500 miligram two numbers every 12 hours, tab bismuth subsalicylate 120 miligram two numbers every 12 hours, tab pantoprazole 20 miligram one number daily, tab gemifloxacin 320 miligram one number daily for 10 days period Helicobacter pylori eradication. Timepoint: 12 weeks. Method of measurement: Ureas Breath Test with C14. Comparision of two quadriple regimen amoxicillin, bismuth subsalicylate, pantoprazole, clarythromycin and amoxicillin, bismuth subsalicylate, pantoprazole, gemifloxacin in eradication of H.pylori infection. Timepoint: 8-12 weeks. Method of measurement: UBT. Guilan Univercity of Medical Sciences Approved 2010-09-23 Guilan University of Medical Sciences. Ethics Committee of Gastrointestinal and Liver Diseases Resea Sardar Jangal Ave, Gastrointestinal and Liver Diseases Research Center, Razi Hospital, Rasht, Iran Rasht Iran (Islamic Republic of)