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IRCT201010022622N2 IRCT 2011-03-05 Tehran Heart Center The prednisolone prescription effect on post CABG surgery inflammatory mediators Comparing the effect of continuous infusion of low dose Methyl Prednisolone with its single dose on reducing the inflammatory mediators and improvement of renal function in patients who undergo open heart surgery 2010-11-11 anticipated 100 Complete https://irct.ir/trial/2405 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2 coronary artery disease. Intervention 1: In control group 15mg/Kg Prednisolone bolus dose before operation and after sedation will be prescribed. After operation this group will be had steady infusion of normal saline (2mg/Kg/d). Intervention 2: Intervention group will be prescribed 1mg/Kg dose of prednisolone (bolous dose) before operation and 2mg/Kg/d as infusion after that.
public Dr. Khosrow Barkhordari
North Kargar Ave. Before Jalal-e Al Ahmad highway
Tehran Iran (Islamic Republic of) 1411713138 +98 21 8802 9600 Kbarkhordari@sina.tums.ac.ir Tehran Heart Center scientific Dr. Neda Ghaffari Marandi
North Kargar Ave. Before Jalal-e Al Ahmad highway
Tehran Iran (Islamic Republic of) 1411713138 +98 21 8802 9600 Ghaffari_15255@yahoo.com Tehran Heart Center Iran (Islamic Republic of) Inclusion criteria:1- age over 18. 2- written informed consent. 3- patients who are candidate for open heart surgery. Exclusion criteria: 1- recent use of systemic corticosteroid. 2- history of bacterial or fungal infection in the past two weeks. 3- history of sensitivity to corticosteroids. 4- uncontrolled diabetes mellitus. 5- history of renal failure 6- liver failure or elevated liver enzymes. 18 years 90 years Both I20-I25 Ischaemic heart diseases Placebo Treatment - Drugs In control group 15mg/Kg Prednisolone bolus dose before operation and after sedation will be prescribed. After operation this group will be had steady infusion of normal saline (2mg/Kg/d) Intervention group will be prescribed 1mg/Kg dose of prednisolone (bolous dose) before operation and 2mg/Kg/d as infusion after that. Length of stay in ICU and Intubation time. Timepoint: after transferring the patient to surgery ward. Method of measurement: questionnaire. Reduction of inflammatory mediators. Timepoint: before, 6 and 48 hours following operation. Method of measurement: Blood test. Tehran Heart Center Approved 2011-01-03 Tehran Heart Center Ethic Committee Jalal Al Ahmad & North Kargar cross Tehran Iran (Islamic Republic of)