IRCT2016092629998N1 IRCT 2016-10-30 Salamat negar Hekmat pazhoohan corporation ofof Medical Science Traditional Medical School of Tehran Assessment of Modiff effect on xerostomia Randomized double blind clinical trial for assessing the effect of Modiff versus placebo on radiation induced xerostomia of head and neck patients. 2016-10-22 anticipated 30 Complete https://irct.ir/trial/23978 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2 xerostomia. Intervention 1: intervention group:Modiff drug.the combination of Althea and Plantago psyllium and mallow.5 gram saschet. every 8 houres each saschet dissolve in 1 glass of water .drinl daily for 3mounths. Intervention 2: placebo group:each sachet contains 5 gram wheat flour plus food colouring produced by Magnolia company. every 8 houres each saschet dissolve in 1 glass of water .drinl daily for 3mounths.

public Saeedeh Archang

Cancer Institue of Imam Khomeyni Hospita Complexl, Keshavarz Boulvar

Tehran Iran (Islamic Republic of) +98 21 6119 2585 saeedeh.archang@yahoo.com Cancer Institue of Imam Khomeyni Hospital Complex scientific Ali Kazemian MD

Cancer Institue of Imam Khomeyni Hospita Complex, Keshavarz Boulvar

Tehran Iran (Islamic Republic of) +98 21 6119 2585 drKazemian@gmaile.com Cancer Institue of Imam Khomeyni Hospital Complex Iran (Islamic Republic of) Inclusion criterias:xerostomia at least grade 2 based on Avraham Eisbruch trial's grading(grade1:no malfunction, grade 2:need to exess fluid to swallow, grade 3: changes in nutririon ,sleep,speech and other activities); taking more than 40gray radition to head and neck to be more than three major salivary glands in the radition field;age of 18 years and older; at least 3 mounths later than the end of the radation. Exclusion criteria:alcohol and other drugs consumption that affect salivary glands like anti depressant;history of connective tissue and collagen vascular diseases like sjogren, rheumatoid arthritis, lupus;systemic or local reccurents;need to prenteralnutrition hospitalsation. no limit no limit Both K11.7 Disturbances of salivary secretion Treatment - Drugs Treatment - Drugs intervention group:Modiff drug.the combination of Althea and Plantago psyllium and mallow.5 gram saschet. every 8 houres each saschet dissolve in 1 glass of water .drinl daily for 3mounths placebo group:each sachet contains 5 gram wheat flour plus food colouring produced by Magnolia company. every 8 houres each saschet dissolve in 1 glass of water .drinl daily for 3mounths Saliva amount. Timepoint: 3times in 3 mountes intervals. Method of measurement: collecting saliva in 5 mintusein the 1 scaled test tube. Quality of life. Timepoint: 3times in 3 mountes intervals. Method of measurement: questionare. Constipation. Timepoint: 3times in 3 mountes intervals. Method of measurement: questionare. Skin dryness. Timepoint: 3times in 3 mountes intervals. Method of measurement: questionare. Quality of sleep. Timepoint: 3times in 3 mountes intervals. Method of measurement: questionare. Salamat negar Hekmat pazhoohan corporation ofof Medical Science Traditional Medical School of Tehran Approved 2016-09-24 Research and Study managment of Tehran University of Medical Sciences poorsina avenue, 16azar sreete, Tehran University of Medical Science Tehran Iran (Islamic Republic of)