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IRCT201407242602N12 IRCT 2014-08-22 Iran University Medical Science The effect of hesperidin in the treatment of diabetes Effect of Supplementation of Hesperidin on Serum Glucose, Insulin, Insulin Resistance, Lipid Profile, Hemoglobin A1C, hs-CRP and IL6 in Type II Diabetic Mellitus Patients 2014-09-10 anticipated 48 Complete https://irct.ir/trial/2381 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 3 diabet. Intervention 1: Hesperidin, Capsules 500 mg, 1 time a day for 2 months. Intervention 2: Starch placebo capsules, 500 mg, 1 time a day for 2 months.
public Shahryar Eghtesadi
Hemmat Highway, Iran University of Medical Sciences, School of Public Health
Tehran Iran (Islamic Republic of) +98 218670475 egtesadi@iums.ac.ir, eghtesadi@yahoo.com Iran University Medical School scientific Shahryar Eghtesadi
Hemmat Highway, Iran University of Medical Sciences, School of Public Health
Tehran Iran (Islamic Republic of) +98 218670475 egtesadi@iums.ac.ir, eghtesadi@yahoo.com Iran University Medical School Iran (Islamic Republic of) Inclusion criteria: Being volunteer or Wishing to attend 2.diagnosed with type 2 diabetes for at least 1 year (FPG ≥ 126 mg/dl or 2hPG ≥ 200 mg/dl)3. At least one year history of diabet 4. Not using tobacco 5. Lack of cardiovascular disease, liver disease, kidney disease, chronic inflammatory disease of the gastrointestinal tract 6.HbA1C < 8% 7. 20-65 y old 8. Lack of insulin 9. Not drinking alcohol 10. BMI<35 kg/m2 11. Not using any supplements, antioxidants and vitamins in the last 3 months 12. Not pregnant or nursing 13.TG<400 mg/dl 14. The absence of any skin allergies or digestive antioxidant supplements and vitamins. Exclusion criteria 1.The use of antioxidant supplements and vitamins 2.Use of insulin 3. See allergy symptoms at any time during the study 4.Taking over500ml beverages rich in flavonoids include tea, coffee, citrus juice, which it is determined by taking the 24-hour dietary recalls 5. Accept less than 70 6. Follow weight loss diets 7. NSAID nonsteroidal anti-inflammatory drugs and estrogens, oral contraceptives, anticonvulsants, corticosteroids 20 years 65 years Both E11 Non-insulin-dependent diabetes mellitus Treatment - Drugs Placebo Hesperidin, Capsules 500 mg, 1 time a day for 2 months Starch placebo capsules, 500 mg, 1 time a day for 2 months IL6. Timepoint: After the. Method of measurement: ELISA based on a scale pg / ml. Hs CRP. Timepoint: After the intervention. Method of measurement: ELISA based on a scale ng / ml. Glucose. Timepoint: Before the intervention and after the intervention. Method of measurement: Glucose oxidase method based on scale mg / dl. Insulin. Timepoint: Before the intervention and after the intervention. Method of measurement: ELISA based on a scale μmol / ml. Glycated hemoglobin. Timepoint: Before the intervention and after the intervention. Method of measurement: Chromatography based on the percentage of glycated hemoglobin. TG. Timepoint: Before the intervention and after the intervention. Method of measurement: By an enzymatic method based on the scale mg / dl. TC. Timepoint: Before the intervention and after the intervention. Method of measurement: By an enzymatic method based on the scale mg / dl. LDL. Timepoint: Before the intervention and after the intervention. Method of measurement: To help Frydvald formula based on mg / dl. HDL. Timepoint: Before the intervention and after the intervention. Method of measurement: By an enzymatic method based on the scale mg / dl. Systolic blood pressure. Timepoint: Before the intervention and after the intervention. Method of measurement: Using a pressure gauge based on a scale mm Hg. Diastolic blood pressure. Timepoint: Before the intervention and after the intervention. Method of measurement: Using a pressure gauge based on a scale mm Hg. Insulin Resistance. Timepoint: Before the intervention and after the intervention. Method of measurement: Using the formula. Age. Timepoint: Before the intervention and after the intervention. Method of measurement: Using Balance 0/1kg carefully based on kg scale. BMI. Timepoint: Before the intervention and after the intervention. Method of measurement: Using the formula. Physical activity. Timepoint: Before the intervention and after the intervention. Method of measurement: Using a questionnaire, based on three levels of light, medium and heavy. Dietary intake. Timepoint: Before the intervention and after the intervention. Method of measurement: based on a 3-day recall measure kcal. Gender. Timepoint: before the intervention. Method of measurement: Using view on men or women. Types of drugs. Timepoint: Before the intervention and after the intervention. Method of measurement: Using a questionnaire based on observation. Dose of drugs. Timepoint: Before the intervention and after the intervention. Method of measurement: Using a questionnaire based on the number of. Iran University Medical Science Approved 2014-07-14 School of Public Health, Iran University of Medical Sciences Hemmat Highway, Iran University of Medical Sciences Tehran Iran (Islamic Republic of)