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IRCT2016082129451N1 IRCT 2016-10-02 Vice chancellor for research, Shiraz University of Medical Sciences Evaluation of prophylactic effect of aloe vera gel on radiation induced dermatitis in breast cancer patients. Evaluation of prophylactic effect of aloe vera gel on radiation induced dermatitis in breast cancer patients. 2015-11-30 anticipated 100 Complete https://irct.ir/trial/23664 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. 2 Breast cancer. Intervention 1: Intervention group: all breast cancer patients with partial mastectomy that assigned to this group randomly and all of them receive standard radiotherapy. radiation doses was 50 Gy in 25 fractions by linac machine ( 6mv photon) and Aloe vera gel was applied twice a day with a thickness of 1-2 mm on the radiation therapy field from first day. 6-hour time period is recommended between two application of aloe vera gel. Intervention 2: Control group: All breast cancer patients with partial mastectomy that assigned to this group randomly, should receive radiotherapy. Radiation doses was 50 Gy in 25 fractions by linac machine (6mv photon).The patients did not receive any medication .
public Dr.Behnam kadkhodaei
Zand AVE, Namazee SQ, Radiation Oncology Ward, Namazee Hospital
Shiraz Iran (Islamic Republic of) 71937-11351 +98 71 3212 5337 stud5479613324@sums.ac.ir Shiraz University of Medical Sciences scientific Dr.Niloofar Ahmadloo
Zand AVE, Namazee SQ, Radiation Oncology Ward, Namazee Hospital
Shiraz Iran (Islamic Republic of) 71937-11351 +98 71 3212 5337 ahmadloo@sums.ac.ir Shiraz University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: New diagnosed breast cancer patients with partial mastectomy who need to receive radiation therapy; All ages; Female; No previous radiotherapy to breast area; No systemic and dermatologic disease; The median time interval between end of chemotherapy and the beginning of irradiation ranged between 3 and 4 weeks. Exclusion criteria: Having poor follow up; Stopping radiotherapy by patient herself; The patient refuse to using aloe Vera gel; Using other local drugs concurrently. no limit no limit Female C50.9 Breast, unspecified Treatment - Drugs Treatment - Other Intervention group: all breast cancer patients with partial mastectomy that assigned to this group randomly and all of them receive standard radiotherapy. radiation doses was 50 Gy in 25 fractions by linac machine ( 6mv photon) and Aloe vera gel was applied twice a day with a thickness of 1-2 mm on the radiation therapy field from first day. 6-hour time period is recommended between two application of aloe vera gel. Control group: All breast cancer patients with partial mastectomy that assigned to this group randomly, should receive radiotherapy. Radiation doses was 50 Gy in 25 fractions by linac machine (6mv photon).The patients did not receive any medication . Grading of dermatitis. Timepoint: weekly. Method of measurement: Rtog scoring for radiation induced dermatitis. Treatment interruption. Timepoint: weekly. Method of measurement: Review of the patient's medical file. Vice chancellor for research, Shiraz University of Medical Sciences Approved 2016-08-27 Shiraz medical school ' Ethics Committee Zand AVE, Namazee SQ, Shiraz medical school Shiraz Iran (Islamic Republic of)