IRCT2016090328950N2 IRCT 2017-01-10 Shahid Sadoughi University of Medical Sciences, Vice chancellor for research Evaluation of intrauterine infusion of autologous platelet rich plasma (PRP) on in vitro fertilization (IVF) Clinical trial of pregnancy outcome in women with thin endometrium after intrauterine infusion of autologous platelet rich plasma (PRP) in comparison with women with thin endometrium without intervention undergoing frozen thawed cycles 2016-09-22 anticipated 66 Complete https://irct.ir/trial/23377 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: Randomized with table of random numbers with computerized software. 3 female infertility. Intervention 1: Intervention group: In 2nd day of cycle the patients undergo a basic trans vaginal sonography. For all the women who enter in frozen thawed cycles, estradiol tablet 2mg three times daily is initiated. In 13th day of cycle trans vaginal sonograghy is done for the patients again. Those who have endometrial thickness below 7mm enter in the study. PRP is infused intrauterine with IUI (intra uterine insemination) catheter. Endometrial thickness is measured after 48 hours. If endometrial thickness doesn't reach 7mm or above, the second dose of PRP will infuse. After 48 hours the endometrial thickness is measured and for whom with endometrial thickness above 7mm vaginal suppository Progesterone400 mg twice daily is prescribed for 3 days then embryos in cleavage state are transferred. Intervention 2: Control group: In 2nd day of cycle the patients undergo a basic trans vaginal sonography. For all the women who enter in frozen thawed cycles, estradiol tablet 2mg three times daily is initiated. In 13th day of cycle trans vaginal sonograghy is done for the patients again. Those who have endometrial thickness below 7mm enter in the study. They are divided in 2 groups randomly. In control group estradiol is continued for another 3 days .When endometrial thickness reaches 7mm or above, vaginal suppository Progesterone400 mg twice daily is prescribed for 3 days then embryos in cleavage state are transferred .