IRCT2017091428815N2 IRCT 2017-09-28 Vice-chancellery for Research of Mashhad University of Medical Sciences Results and complications of intraoperative radiotherapy as boost after neoadjuvant chemotherapy A clinical trial evaluating the results and complications of intraoperative radiotherapy as boost after neoadjuvant chemotherapy in patients with nonmetastatic breast cancer candidate for breast conserving surgery 2017-02-09 anticipated 20 Complete https://irct.ir/trial/23281 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. 2 Breast cancer. a detectable marker will be inserted under the guide of sonography in the tumor. Afterwards, the patients will receive neoadjuvant chemotherapy based on the standards of the treating institute. Before each course of chemotherapy, the patients will be examined for clinical response to chemotherapy. At the end of neoadjuvant treatment, the patients will undergo full physical examination and mammographic and sonographic assessment. In case of appropriate clinical response, the patients will undergo lumpectomy two weeks after completion of neoadjuvant treatment. During surgery, the patients will receive 20 gray intraoperative radiotherapy by intrabeam system Zeiss. After surgery, the patients will receive external beam radiotherapy (50 gray to the whole breast and 45 to 50 gray to the supraclavicular lymph node). Patients will be followed up every 3 months during the first 2 year, and then every 6 months until 5 years by physical examination and annual mammography (or sonography in case of dense breast)..