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IRCT2016062828679N1 IRCT 2016-09-08 Reaerch Deputy of Kurdistan University of Medical Sciences Effects of Propolis intake on nutritional status, some inflammatory and anti-inflammatory factors and quality of life in patients with Breast Cancer undergoing chemotherapy. Effects of Propolis intake on nutritional status, matrix metalloproteinase enzymes, inflammatory, anti-inflammatory and oxidative factors and quality of life in patients with Breast Cancer undergoing chemotherapy. 2016-09-22 anticipated 70 Complete https://irct.ir/trial/23205 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2 Breast Cancer. Intervention 1: A week before the start of chemotherapy in intervention group, 250 mg propolis extract divided in two 125 mg capsules will administered twice daily with breakfast and lunch until the end of treatment (3 months). Intervention 2: A week before the start of chemotherapy in the placebo group, starch capsules with dose of 250 mg (125 mg twice daily) will administered with breakfast and lunch until the end of treatment (3 months).
public Nazila Darvishi
No 23, Gole Narges Alley, Hafez Str
Sanandaj Iran (Islamic Republic of) +98 87 3366 9313 naziladarvishy@yahoo.com Shahid Beheshti University of Medical Sciences scientific Nazila Darvishi
No 23, Gole Narges Alley, Hafez Str
Sanandaj Iran (Islamic Republic of) +98 87 3366 9313 naziladarvishy@yahoo.com Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Stage II and III Breast cancer under chemotherapy; age range 30 to 50 years. Exclusion criteria: heart disease co morbidity; history of hypersensitivity reactions to bee products. 30 years 50 years Female C50.9 Malignant neoplasm: Breast, unspecified Treatment - Drugs Placebo A week before the start of chemotherapy in intervention group, 250 mg propolis extract divided in two 125 mg capsules will administered twice daily with breakfast and lunch until the end of treatment (3 months). A week before the start of chemotherapy in the placebo group, starch capsules with dose of 250 mg (125 mg twice daily) will administered with breakfast and lunch until the end of treatment (3 months) Interlukin b1, 2, 10. Timepoint: Baseline and after intervention. Method of measurement: Elisa, ng/ml. TNF-α. Timepoint: Baseline and after intervention. Method of measurement: Elisa, ng/ml. MMP-2, 9. Timepoint: Baseline and after intervention. Method of measurement: Elisa, ng/ml. Anti oxidant Ezymes. Timepoint: Baseline and after intervention. Method of measurement: Elisa, nmol/l. Nutritional Status. Timepoint: Baseline and after intervention. Method of measurement: PGSGA questionner. Mir 21. Timepoint: Baseline and after intervention. Method of measurement: Fold. Mir638. Timepoint: Baseline and after intervention. Method of measurement: Fold. Quality of life. Timepoint: Baseline and after intervention. Method of measurement: EORTC QLQ30. Chemotrapy Complication. Timepoint: Baseline and after intervention. Method of measurement: questionner. Liver Enzymes. Timepoint: Baseline and after intervention. Method of measurement: Eliza, IU/L. Reaerch Deputy of Kurdistan University of Medical Sciences Approved 2016-06-13 Ethics committee of Kurdistan University of Medical Sciences Opposite of Shadi Hotel, Pasdaran Str Sanandaj Iran (Islamic Republic of)