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IRCT2016060528260N1 IRCT 2016-07-05 Vice Chancellor for research of Kermanshah University of Medical Sciences Effect of L carnitine on Coronary Artery Disease Patients Outcome Effects of L-carnitine Supplementation on Body composition, Oxidative stress and Inflammatory factors in patients with Coronary Artery Disease: A Randomized Clinical Trial 2016-06-21 anticipated 60 Complete https://irct.ir/trial/22950 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive. N/A Coronary Artery Disease(CAD). Intervention 1: Intervention group: will receive two L carnitine 500 mg tablets (made in karen company) twice a day (with breakfast and dinner) for 12 weeks . Intervention 2: Control group: will receive quite similar tablets (in terms of shape and color and packaging. ..) containing soluble starch with the same dose and time-consuming.
public Maryaam Shabanpur
Dolat Abad, School of Public Health
Kermanshah Iran (Islamic Republic of) +98 83 3826 2005 maryam.shabanpur@yahoo.com Kermanshah University of Medical Science, School of Public Health scientific Dr Seyyed Mostafa Nachvak
Dolat abad, School of Public Health
Kermanshah Iran (Islamic Republic of) +98 83 3826 2005 smnachvak@hotmail.com Assistant Professor, Department of Nutrition, School of Public Health, Kermanshah University of Medi Iran (Islamic Republic of) Inclusion criteria: patients having at least 50% stenosis of one major coronary artery or receiving percutaneous transluminal coronary angioplasty (PTCA). Exclusion criteria: The patients with diabetes, liver, or renal diseases will be excluded. The patients under medications therapy, such as acenocoumarol, thyroid hormone, and warfarin, and those currently receiving vitamin supplements will also be excluded. no limit no limit Both I20-I25 Ischaemic heart diseases Treatment - Other Treatment - Drugs Intervention group: will receive two L carnitine 500 mg tablets (made in karen company) twice a day (with breakfast and dinner) for 12 weeks . Control group: will receive quite similar tablets (in terms of shape and color and packaging. ..) containing soluble starch with the same dose and time-consuming Hs-CRP. Timepoint: before and after. Method of measurement: ELISA assay. Myeloproxidase(MPO). Timepoint: before and after. Method of measurement: ELISA assay. Nitrityrosine(NT). Timepoint: before and after. Method of measurement: ELISA assay. Total antioxidant capacity(TAC). Timepoint: before and after. Method of measurement: Colorimetric assay. Body composition. Timepoint: At first and the end of sixth and twelfth weeks of the study. Method of measurement: body Analyzers Jown Plus (Avis 333). Evalution of patients diet. Timepoint: At first and the end of sixth and twelfth weeks. Method of measurement: 24 hour recall questionare. The level of physical activity. Timepoint: at first and the end of sixth and twelfth weeks of study. Method of measurement: IPAQ questionare. Blood pressure. Timepoint: at first and the end of study. Method of measurement: By mercury sphygmomanometer. Vice Chancellor for research of Kermanshah University of Medical Sciences Approved 2016-05-11 Ethics Committee, Kermanshah University of Medidcal Science Shahid Beheshti Boulevard, Number 2 Building of Kermanshah University of medical science Kermanshah Iran (Islamic Republic of)