IRCT2016052828129N1 IRCT 2016-06-05 Vice chancellor for research, Ahwaz Judishapur University of Medical Sciences The effect of Alprostadil on improvement of acute asthma attack Comparing the effect of Alprostadil administration with routine cares on improvement of forced expiratory volume in 1 second, peak expiratory flow rates and clinical indexes of patients with acute asthma attack 2016-04-27 anticipated 28 Complete https://irct.ir/trial/22886 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 Asthma. Intervention 1: Patients in intervention will receive 2 mcg/kg/min intravenous Alprostadil and Albuterol with 20 minutes interval in three dosages via inhalation. Intervention 2: Patients in control group will receive treatment based on their asthma attack severity. In mild to moderate attacks, patients will receive 2.5 mg Albuterol and 0.5 mg Ipratropium Bromide via inhalation with 20 minutes interval in three dosages. Patients with severe asthma attack will receive 5 mg Albuterol and 0.5 mg Ipratropium Bromide via inhalation with 20 minutes interval in three dosages, and will receive Prednisolone via oral.