IRCT2016052428043N1 IRCT 2016-12-09 Vice chancellor of Ahvaz Jundishapur University of Medical Sciences Efficacy of combined extract of Nigella Sativa and Thymus Vulgaris on refractory seizures in children Efficacy of combined extract of Nigella Sativa and Thymus Vulgaris on refractory seizures in children 2016-12-10 anticipated 30 Complete https://irct.ir/trial/22840 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Crossover, Purpose: Treatment. N/A epilepsy. Intervention 1: intervention group: patients with age 3-12 years receive 5cc of prepared extract(115 mg of extract is found in 5 cc of prepared drug) three times a day and patients with age >12 years receive 7.5 cc of prepared extract three times a day for two months. Then all the patients will be evaluated for two weeks (as washout period) after two months in the terms of duration and the frequency of epilepsy and side effects. Then the prepared placebo will be administrated foranother two months. Intervention 2: contorol group: patients with age 3-12 years receive 5cc of prepared placebo three times a day and patients with age >12 years receive 7.5 cc of prepared plasebo three times a day for two months. Then all the patients will be evaluated for two weeks (as washout period) after two months in the terms of duration and the frequency of epilepsy and side effects. Then the prepared extracts extract(115 mg of extract is found in 5 cc of prepared drug )with the same dosage as adjunctive therapy will be administrated for another two months.