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IRCT2016051927969N1 IRCT 2016-07-09 Vice chancellor for research, Mashhad University of Medical Sciences The Effect of Nose Disinfection with Chlorhexidine on Respiratory Infection The Effect of Nose and Mouth Disinfection with Chlorhexidine on indicators of respiratory infections in intubated patients with mechanical ventilation 2016-06-21 anticipated 70 Complete https://irct.ir/trial/22798 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. N/A Pneumonia. Intervention 1: In the intervention group, mouthwash (disinfection cheeks, gums, palate, tongue and teeth) every 8 hours with 10 ml of ready solution of 0.2% chlorhexidine is performed by the applicator for 30 second. Also every 8 hours after oral antiseptic, anti-infectious of nasal anterior openings is performed with 0.2% chlorhexidine solution by cotton swab. This continues until the end of the fifth day of mechanical ventilation. Intervention 2: In the control group, mouthwash (disinfection cheeks, gums, palate, tongue and teeth) every 8 hours with 10 ml of ready solution of 0.2% chlorhexidine is performed by the applicator for 30 second. This continues until the end of the fifth day of mechanical ventilation. In this group is not done disinfection of nose.
public Mahdi Alimi
Qoreishi Building, Daneshgah St, Mashhad
Mashhad Iran (Islamic Republic of) +98 51 3366 1500 alimim1@mums.ac.ir Mashhad University of Medical Sciences scientific Zahra Sadat Manzari
Faculty of Nursing and Midwifery, Ibn-e Sina St, Chaharah Doktora Crossing, Mashhad
Mashhad Iran (Islamic Republic of) +98 51 3859 1511 nms.it[at]mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Inclusion Criteria: The satisfaction of patient's attendant to participate in the study; The patient's age is more than 18 years; The patient has endotracheal tube through the mouth; The patient has not nasogastric tube; Expecting mechanical ventilation for at least 48 hours; On arrival to the ICU lung infiltration on chest radiograph Does not exist; At least two of the three clinical criteria indicators of ventilator associated pneumonia (rectal temperature less than 35 or more than 38 degrees Celsius, leukocyte count of less than 4,000 or more than 12,000 per cubic millimeter of blood and purulent tracheal secretions) does not exist. Exclusion criteria: desire to continue participation in the study; Allergic reaction to chlorhexidine; Clear aspiration; At least two of the three clinical criteria indicators of ventilator associated pneumonia exist in the first or second day of mechanical ventilation 18 years no limit Both J18.9 Pneumonia, unspecified Prevention Prevention In the intervention group, mouthwash (disinfection cheeks, gums, palate, tongue and teeth) every 8 hours with 10 ml of ready solution of 0.2% chlorhexidine is performed by the applicator for 30 second. Also every 8 hours after oral antiseptic, anti-infectious of nasal anterior openings is performed with 0.2% chlorhexidine solution by cotton swab. This continues until the end of the fifth day of mechanical ventilation. In the control group, mouthwash (disinfection cheeks, gums, palate, tongue and teeth) every 8 hours with 10 ml of ready solution of 0.2% chlorhexidine is performed by the applicator for 30 second. This continues until the end of the fifth day of mechanical ventilation. In this group is not done disinfection of nose. Amount of Body Temperature. Timepoint: up to Five Days after beginning of Intervention. Method of measurement: By Glass Thermometer for Axillary in Degrees Celsius. Amount of Tracheal secretions. Timepoint: up to Five Days after beginning of Intervention. Method of measurement: Based on The Required Frequency of Tracheal Suctioning. Kind of Tracheal secretions. Timepoint: up to Five Days after beginning of Intervention. Method of measurement: On the basis of color, odor and secretions concentration and according to the nurse caring for the patient. Amount of Blood leukocytes. Timepoint: up to Five Days after beginning of Intervention. Method of measurement: By blood test. Ratio of Arterial Oxygenation. Timepoint: up to Five Days after beginning of Intervention. Method of measurement: By Analyze of Arterial Blood Gases. Changes of Chest radiographic. Timepoint: up to Five Days after beginning of Intervention. Method of measurement: By the removable radiological devices (portable). Culture of tracheal secretions. Timepoint: up to Five Days after beginning of Intervention. Method of measurement: Quantitative culture with Gram stain. Ventilator associated Pneumonia. Timepoint: Up to five days after beginning of intervention. Method of measurement: By Clinical Pulmonary Infection Score. The relationship between clinical criteria and diagnosis of pneumonia. Timepoint: Up to five days after beginning of intervention. Method of measurement: By Clinical Pulmonary Infection Score. Vice chancellor for research, Mashhad University of Medical Sciences Approved 2015-11-07 The ethics committee of Mashhad University of Medical Sciences Qoreishi Building, Daneshgah St, Mashhad Mashhad Iran (Islamic Republic of)