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IRCT20160318027097N6 IRCT 2017-12-12 Vice Chancellor for research of Ardebil University of Medical Sciences Treatment of Helicobacter Pylori infection in patients with dyspepsia Comparison of three therapeutic regimens (Rabiprazole, Amoxicillin, Bismuth subcetate, Clarithromycin (1), Rabiprazole, Amoxicillin, Clarithromycin (2) Rabiprazole, Amoxicillin, Bismuth subcetate, Furazolidone (3)) in eradication of Helicobacter pylori in 2017-12-16 anticipated 90 Complete https://irct.ir/trial/22287 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: 90 numbers will enter the random block, and randomly the numbers are divided into three groups. Accordingly, patients will receive one of three regimens with their randomly pre-assigned number, Randomization description: The randomization is block, individual and using a random number table in this study. 90 numbers will entered the random block and numbers are randomly assigned into three groups. Accordingly, the patients will receive one of three regimens with their randomly assigned number. In this study, participants, researchers are unaware of prescription drugs. 2-3 Dyspepsia. Intervention 1: Case group (2): Rabiprazole, Tablet 40mg oral OD for 6 weeks. Amoxicillin, Tablet 1000mg oral BD for 2 weeks. Clarithromycin, Tablet 500mg oral BD for 2 weeks. Intervention 2: Case group (3): Rabiprazole, Tablet 40mg oral OD for 6 weeks. Amoxicillin, Tablet 1000mg oral BD for 2 weeks. Bismuth subcitrate, Tablet 120mg oral BD for 2 weeks. Furazolidone Tablet 200mg oral BD for 2 weeks. Intervention 3: Case group (1): Rabiprazole, Tablet 40mg oral OD for 6 weeks. Amoxicillin, Tablet 1000mg oral BD for 2 weeks. Bismuth subcitrate, Tablet 120mg oral BD for 2 weeks. Clarithromycin Tablet 500mg oral BD for 2 weeks. Yes - There is a plan to make this available What will be shared: Total potential data after unidentifiable individuals When: Start the access period from 2019 To whom: Researchers in academic and scientific institutions Conditions: Data can be used for scientific and research studies. Where to obtain: Dr Masoud Tasoji; Internal Medicine Assistant; M.tasoji@arums.ac.ir How to obtain: After receiving the request email, data files will be sent in less than a week. Comments:
public Dr Masoud Tasoji
Ardebil University of Medical Sciences, Daneshgah Avenue, Ardebil, Iran
Ardebil Iran (Islamic Republic of) 5163639888 +98 45 3351 2006 naghizadeh73@yahoo.com Ardebil University of Medical Sciences scientific Dr Mohammad Sadrkabir
Ardebil University of Medical Sciences, Daneshgah Avenue, Ardebil, Iran
Ardebil Iran (Islamic Republic of) 5163639888 +98 45 3351 2006 M.sadrkabir@arums.ac.ir Ardebil University of Medical Sciences Iran (Islamic Republic of) Endoscopic and biopsied patients; Report of the Helicobacter pylori organism in the tissue sample. no limit no limit Both Pregnancy; Intolerance to drugs; Interaction with medications such as digoxin; drug complications during treatment. K30 Dyspepsia Treatment - Drugs Treatment - Drugs Treatment - Drugs Case group (2): Rabiprazole, Tablet 40mg oral OD for 6 weeks. Amoxicillin, Tablet 1000mg oral BD for 2 weeks. Clarithromycin, Tablet 500mg oral BD for 2 weeks Case group (3): Rabiprazole, Tablet 40mg oral OD for 6 weeks. Amoxicillin, Tablet 1000mg oral BD for 2 weeks. Bismuth subcitrate, Tablet 120mg oral BD for 2 weeks. Furazolidone Tablet 200mg oral BD for 2 weeks Case group (1): Rabiprazole, Tablet 40mg oral OD for 6 weeks. Amoxicillin, Tablet 1000mg oral BD for 2 weeks. Bismuth subcitrate, Tablet 120mg oral BD for 2 weeks. Clarithromycin Tablet 500mg oral BD for 2 weeks Fecal antigen of Helicobacter pylori. Timepoint: 4 weeks after Intervention. Method of measurement: ELISA. Vice Chancellor for research of Ardebil University of Medical Sciences Approved 2017-07-24 Ethics committee of Ardebil University of Medical Sciences Ardebil University of Medical Sciences, daneshghah ave, Ardebil, Iran Ardebil Ardabil Iran (Islamic Republic of)