]>
IRCT2016022126685N1 IRCT 2016-06-04 Ahvaz Jundishapur University Of Medical Sciences, Ahvaz, Iran The effect of intravenous Magnesium Sulfate versus an analgesic on the duration of Spinal anesthesia and post-operative pain in patients with leg fracture. The effect of intravenous Magnesium Sulfate versus intravenous Sufentanil on the duration of Spinal anesthesia and post-operative pain in patients with leg fracture. 2016-07-28 anticipated 70 Other https://irct.ir/trial/22044 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A leg fracture. Intervention 1: control group: In the second group, 8mg/kg/h Magnesium sulfate(10% Intravenous), in a quite similar way, should be diluted in 1liter of ringer and after an hour, after ensuring about the completion of anesthesia, Infusion will be done. All the patients were under spinal anesthesia, with 10 mg of Bupivacaine(10%), In a sitting position, with the needle no. 25 and by Selecting the L4-L5 space and Nvragzyal block and failure to understand the sharpness of the needle in T10 dermatom, Patients are undergoing a surgery. After the Spinal anesthesia and During the surgery with five minutes Intervals, Systolic and diastolic blood pressure, The percentage of arterial oxygen and heart rate are monitored and If blood pressure decreases by twenty percent or Systolic blood pressure decreases to less than 100mmHg, they will receive Afrdyn (0.5mg), and If blood pressure decreases to less than 60, they will receive Atropine(0.5mg), The dose will be repeated, If needed. As well, all the patients, during the surgery, will receive Oxygen 4 liters per minute. In this study, Onset of anesthesia will be evaluated with Pin Prick way and also, Patients interview about heavy and tingling legs. Complete muscular weakness of lower extremity, following the Spinal Anesthesia, Is considered as a starting for point motor block and the duration of the anesthesia, will be evaluated with the Modified bromage scale. In this way, an hour after the start of operation, the sensory and motor block Condition will be evaluated by examining the normal feet and this evaluation will be continued and recorded an interval of every half an hour, by the end of the return of sensory and motor block recovery. Postoperative pain, will be evaluated by Visual Analog Scale(VAS). After the surgery, All the patients are transferred to recovery and until the end of returning from anesthesia, they will be monitored In terms of heart rate, breathing, the amount of oxygen saturation and also blood pressure. Patients' demographic characteristics are collected, such as; weight, age, gender, height and the length of surgery. Considering the end time of anesthesia in recovery, as the origin of Postoperative pain, after 0, 1, 4, 8, 16, 24 hours, compared to the end of anesthesia has been evaluated and registered and in the case of equal VAS (or more than 3), the patients will receive 30 mg/kg Pethidine intravenously. At the end, the first time of requesting analgesic and also, total analgesic consumption, will be recorded. Intervention 2: Intervention group: After embedding Peripheral venous cannula, we infused 10 cc/kg of Ringer crystalloid to the patients. All the patients were under spinal anesthesia, with 10 mg of Bupivacaine(10%), In a sitting position, with the needle no. 25 and by Selecting the L4-L5 space and Nvragzyal block and failure to understand the sharpness of the needle in T10 dermatom, Patients are undergoing a surgery. In the group which receives Sufentanil, in the group which receives sufentanil, 0.1 kg/h/µ of this Substance should be diluted in 1liter of ringer and after an hour, after ensuring about the completion of anesthesia, Infusion will be done. In all participants, Serum levels of creatinine will be measured before the surgery and after the end of surgery, Patients are moved to the recovery room. After the Spinal anesthesia and During the surgery with five minutes Intervals, Systolic and diastolic blood pressure, The percentage of arterial oxygen and heart rate are monitored and If blood pressure decreases by twenty percent or Systolic blood pressure decreases to less than 100mmHg, they will receive Afrdyn (0.5mg), and If blood pressure decreases to less than 60, they will receive Atropine(0.5mg), The dose will be repeated, If needed. As well, all the patients, during the surgery, will receive Oxygen 4 liters per minute. In this study, Onset of anesthesia will be evaluated with Pin Prick way and also, Patients interview about heavy and tingling legs. Complete muscular weakness of lower extremity, following the Spinal Anesthesia, Is considered as a starting for point motor block and the duration of the anesthesia, will be evaluated with the Modified bromage scale. In this way, an hour after the start of operation, the sensory and motor block Condition will be evaluated by examining the normal feet and this evaluation will be continued and recorded an interval of every half an hour, by the end of the return of sensory and motor block recovery. Postoperative pain, will be evaluated by Visual Analog Scale(VAS). After the surgery, All the patients are transferred to recovery and until the end of returning from anesthesia, they will be monitored In terms of heart rate, breathing, the amount of oxygen saturation and also blood pressure. Patients' demographic characteristics are collected, such as; weight, age, gender, height and the length of surgery. Considering the end time of anesthesia in recovery, as the origin of Postoperative pain, after 0, 1, 4, 8, 16, 24 hours, compared to the end of anesthesia has been evaluated and registered and in the case of equal VAS (or more than 3), the patients will receive 30 mg/kg Pethidine intravenously. At the end, the first time of requesting analgesic and also, total analgesic consumption, will be recorded.
public Mahdis vakili
Ahvaz Jundishapur University Of Medical Sciences, Golestan Ave.
Ahvaz Iran (Islamic Republic of) +98 613367543 mahdisvakili@yahoo.com Ahvaz Jundishapur University Of Medical Sciences, Ahvaz, Iran scientific Maryam Jafari
Imam Khomeini Hospital, Sharif zadeh St, Azadegan Ave.
Ahvaz Iran (Islamic Republic of) +98 914 104 2809 mryamjafari59@yahoo.commahdisvakili@yahoo.com Imam Khomeini Hospital Iran (Islamic Republic of) Iran (Islamic Republic of) Entry requirements; the age group of 18 to 58 years, ASA I,II, BMI: 19-30 Exclusion criteria: Patient refusal; High ICP; Coagulopathy; Skin infection, in the insertion of the needle; Peripheral neuropathy of the lower extremities; Drug and alcohol abuse; Using sedative and antipsychotic drugs and also psychotropic substances; Using calcium channel blockers; Having a history of mental illnesses and also Thyroid Disorders; A history of kidney disorders and cardiac arrhythmias. 18 years 58 years Both S82.7 Multiple fractures of lower leg Treatment - Drugs Treatment - Drugs control group: In the second group, 8mg/kg/h Magnesium sulfate(10% Intravenous), in a quite similar way, should be diluted in 1liter of ringer and after an hour, after ensuring about the completion of anesthesia, Infusion will be done. All the patients were under spinal anesthesia, with 10 mg of Bupivacaine(10%), In a sitting position, with the needle no. 25 and by Selecting the L4-L5 space and Nvragzyal block and failure to understand the sharpness of the needle in T10 dermatom, Patients are undergoing a surgery. After the Spinal anesthesia and During the surgery with five minutes Intervals, Systolic and diastolic blood pressure, The percentage of arterial oxygen and heart rate are monitored and If blood pressure decreases by twenty percent or Systolic blood pressure decreases to less than 100mmHg, they will receive Afrdyn (0.5mg), and If blood pressure decreases to less than 60, they will receive Atropine(0.5mg), The dose will be repeated, If needed. As well, all the patients, during the surgery, will receive Oxygen 4 liters per minute. In this study, Onset of anesthesia will be evaluated with Pin Prick way and also, Patients interview about heavy and tingling legs. Complete muscular weakness of lower extremity, following the Spinal Anesthesia, Is considered as a starting for point motor block and the duration of the anesthesia, will be evaluated with the Modified bromage scale. In this way, an hour after the start of operation, the sensory and motor block Condition will be evaluated by examining the normal feet and this evaluation will be continued and recorded an interval of every half an hour, by the end of the return of sensory and motor block recovery. Postoperative pain, will be evaluated by Visual Analog Scale(VAS). After the surgery, All the patients are transferred to recovery and until the end of returning from anesthesia, they will be monitored In terms of heart rate, breathing, the amount of oxygen saturation and also blood pressure. Patients' demographic characteristics are collected, such as; weight, age, gender, height and the length of surgery. Considering the end time of anesthesia in recovery, as the origin of Postoperative pain, after 0, 1, 4, 8, 16, 24 hours, compared to the end of anesthesia has been evaluated and registered and in the case of equal VAS (or more than 3), the patients will receive 30 mg/kg Pethidine intravenously. At the end, the first time of requesting analgesic and also, total analgesic consumption, will be recorded. Intervention group: After embedding Peripheral venous cannula, we infused 10 cc/kg of Ringer crystalloid to the patients. All the patients were under spinal anesthesia, with 10 mg of Bupivacaine(10%), In a sitting position, with the needle no. 25 and by Selecting the L4-L5 space and Nvragzyal block and failure to understand the sharpness of the needle in T10 dermatom, Patients are undergoing a surgery. In the group which receives Sufentanil, in the group which receives sufentanil, 0.1 kg/h/µ of this Substance should be diluted in 1liter of ringer and after an hour, after ensuring about the completion of anesthesia, Infusion will be done. In all participants, Serum levels of creatinine will be measured before the surgery and after the end of surgery, Patients are moved to the recovery room. After the Spinal anesthesia and During the surgery with five minutes Intervals, Systolic and diastolic blood pressure, The percentage of arterial oxygen and heart rate are monitored and If blood pressure decreases by twenty percent or Systolic blood pressure decreases to less than 100mmHg, they will receive Afrdyn (0.5mg), and If blood pressure decreases to less than 60, they will receive Atropine(0.5mg), The dose will be repeated, If needed. As well, all the patients, during the surgery, will receive Oxygen 4 liters per minute. In this study, Onset of anesthesia will be evaluated with Pin Prick way and also, Patients interview about heavy and tingling legs. Complete muscular weakness of lower extremity, following the Spinal Anesthesia, Is considered as a starting for point motor block and the duration of the anesthesia, will be evaluated with the Modified bromage scale. In this way, an hour after the start of operation, the sensory and motor block Condition will be evaluated by examining the normal feet and this evaluation will be continued and recorded an interval of every half an hour, by the end of the return of sensory and motor block recovery. Postoperative pain, will be evaluated by Visual Analog Scale(VAS). After the surgery, All the patients are transferred to recovery and until the end of returning from anesthesia, they will be monitored In terms of heart rate, breathing, the amount of oxygen saturation and also blood pressure. Patients' demographic characteristics are collected, such as; weight, age, gender, height and the length of surgery. Considering the end time of anesthesia in recovery, as the origin of Postoperative pain, after 0, 1, 4, 8, 16, 24 hours, compared to the end of anesthesia has been evaluated and registered and in the case of equal VAS (or more than 3), the patients will receive 30 mg/kg Pethidine intravenously. At the end, the first time of requesting analgesic and also, total analgesic consumption, will be recorded. Sensory and motor block. Timepoint: An hour after the begining the operation. Method of measurement: Modified Bromage Scale. Pain. Timepoint: After the surgery. Method of measurement: Visual Analog Scale. Ahvaz Jundishapur University Of Medical Sciences, Ahvaz, Iran Approved 2016-02-13 Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Ahvaz Jondishapoor University of Medical Sciences, Golestan Ave. Ahvaz Iran (Islamic Republic of)