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IRCT138706101144N1 IRCT 2008-09-29 Tehran university of medical sciences Anesthetic efficacy of intraoral mucoadhesive Amitriptyline in healthy volunteers Anesthetic efficacy of intraoral mucoadhesive Amitriptyline in healthy volunteers 2008-10-01 anticipated 25 Complete https://irct.ir/trial/220 interventional Randomization: N/A, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2 Anesthetic efficacy of intraoral mucoadhesive Amitriptyline in healthy volunteers. The right or left labial alveolar mucosa of the upper incisor apices will be used for topical anesthesia application. The side will be randomly determined with the table of random numbers. The mucoadhesive amitriptyline and the control patch will be placed on the labial alveolar mucosa and the corresponding contralateral tissue sites..
public Mojgan Alaeddini
Ghods St., Enghelab Ave., P.O. Box: 14155-5583, Postal code: 14174
Tehran Iran (Islamic Republic of) +98 21 8898 6677 malaeddini@sina.tums.ac.ir Dental Reasearch Center scientific Mojgan Alaeddini
Ghods St., Enghelab Ave., P.O. Box: 14155-5583, Postal code: 14174
Tehran Iran (Islamic Republic of) malaeddini@sina.tums.ac.ir Dental Reasearch Center Iran (Islamic Republic of) Inclusion Criteria: Women between the ages of 20 and 40 years Exclusion criteria included systemic conditions (such as cardiovascular diseases, diabetes, renal insufficiency, hepatic dysfunction …..), allergic reactions to antidepressants, pregnancy, history of nerve injury, receiving drugs, neuropathy 20 years 40 years Female The right or left labial alveolar mucosa of the upper incisor apices will be used for topical anesthesia application. The side will be randomly determined with the table of random numbers. The mucoadhesive amitriptyline and the control patch will be placed on the labial alveolar mucosa and the corresponding contralateral tissue sites. Anesthetic. Timepoint: 15, 30, 45 minutes after removal patches. Method of measurement: The pain rating score (PRS) and visual analog scale (VAS) will be measured after insertions of a 27-gauge needle. . Timepoint: At 30 minutes and 24 and 48 hours after the removal of the patch. Method of measurement: Local irritation will be rated as follows: 0 = no irritation, 1 = minimal (blood vessels raised above normal levels), 2 = moderate (beet redness of mucosa, individual blood vessels not discernible) and 3 = severe (blister formation and necrosis evident). Tehran university of medical sciences Approved 2008-03-15 Ethical and research committee of Tehran university of medical sciences Tehran university of medical sciences Tehran Iran (Islamic Republic of)