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IRCT2016022026166N1 IRCT 2016-08-31 Vice chancellor for research of Ahwaz Jundishapour university of medical science Evaluation effect of Pramipexole in patients with migraine and restless legs syndrome at the same time Evaluation effect of Propranolol and Pramipexole compared with Propranolol and placebo on treatment of Migrain headache in patients with Migraine and restless legs syndrome at the same time in patient referred to neurology clinic of Ahwaz Golestan hospital 2015-08-15 anticipated 30 Complete https://irct.ir/trial/21753 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 3 Migrain, restless legs syndrome. Intervention 1: First group will treat with Propranolol 20 mg twice a day and placebo two hour before sleep time for three months . Intervention 2: Second group will treat with Propranolol 20 mg twice a day and Pramipexol 0.7 mg two hours before sleep time for three months .
public Farzaneh Karimian
Farvardin boulevard، Golestan highway، Ahwaz Golestan hospital، Neurology department
Ahwaz Iran (Islamic Republic of) +98 61 3374 3011 karimian.f@ajums.ac.ir Ahwaz jundishapour university of medical science and health services scientific Shahram Rafi
Farvardin boulevard، Golestan highway، Ahwaz Golestan hospital، Neurology department
Ahwaz Iran (Islamic Republic of) +98 61 3374 3011 Dr.rafie_68822@yahoo.com Ahwaz Jondishapour university Iran (Islamic Republic of) Main inclusion criteria: No pregnant weman؛ No menopause weman ؛No history of Alcohol or substance addiction ؛No history of cardiac block or bradycardia؛No history of second cause for restless legs syndrome Main exclusion criteria: Patient who stop continuing the study in each reason; Patient who will be menopause or pregnant 15 years 50 years Both G43, G26 Migraine, Other extrapyramidal and movement disorders Treatment - Drugs Treatment - Drugs First group will treat with Propranolol 20 mg twice a day and placebo two hour before sleep time for three months . Second group will treat with Propranolol 20 mg twice a day and Pramipexol 0.7 mg two hours before sleep time for three months . Severity of Miigrain. Timepoint: Start and after 3 months. Method of measurement: Midas questionary. Severity of restless leg syndrome. Timepoint: Start and after 3 months. Method of measurement: IRLLG questionary. Vice chancellor for research of Ahwaz Jundishapour university of medical science Approved 2015-08-15 Morality committee of Ahwaz Jundishapour university of medical science and health services Ahwaz Jundishapour university of medical science and health services، Farvardin boulevard، Golestan highway Ahwaz Iran (Islamic Republic of)