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IRCT2016011825957N2 IRCT 2016-02-09 Oil Version Factory The effect of olive oil in the treatment of non-alcoholic fatty liver disease Compare the effect of olive oil and sunflower oil on insulin resistance and oxidative stress and inflammatory markers in overweight patients with nonalcoholic fatty liver 2015-11-03 anticipated 80 Complete https://irct.ir/trial/21644 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A Nonalcoholic fatty liver. Intervention 1: The intervention group consisted of 40 patients. Randomly placed in this group. 20 grams per day for 3 months receive olive oil. Diet and recommendations are presented separately for each person. The exact consumption of oil is measured by graded modules. Outcomes measured before and after the intervention. At the beginning and end of study and end of each month, 3-day recall, blood pressure and anthropometric indices will be taken. Blood samples were also collected before and after the intervention. Intervention 2: The intervention group consisted of 40 patients. Randomly placed in this group. 20 grams per day for 3 months receive sunflower oil. Diet and recommendations are presented separately for each person. The exact consumption of oil is measured by graded modules. Outcomes measured before and after the intervention. At the beginning and end of study and end of each month, 3-day recall, blood pressure and anthropometric indices will be taken. Blood samples were also collected before and after the intervention.
public Doctor M. Akhlaghi
Razi Blvd
Shiraz Iran (Islamic Republic of) +98 71 3725 1005 shahlarezaei13932014@gmail.com Shiraz University Of Medical Sciences scientific Doctor M.Akhlaghi
Razi Blvd
Shiraz Iran (Islamic Republic of) +98 71 3725 1005 shahlarezaei13932014@gmail.com Department of Nutrition and Food Science Iran (Islamic Republic of) Inclusion criteria: having NAFLD by medical diagnosis (using ultrasound); BMI = 25 and above; willingness to participate in the study, the absence of diabetes mellitus type 2;heart disease; cardiovascular and liver disease (cirrhosis, liver disease Alcohol, viral hepatitis, autoimmune hepatitis, primary biliary cirrhosis, biliary obstruction, liver damage induced by drugs hereditary Hemochromatosis, sclerosis cholangitis and antitrypsin deficiency of α-a-1);other serious diseases such as cancer; kidney failure and celiac disease, etc); lack of pregnancy ;lactation; lack of drugs that are causing fatty liver (methotrexate, tamoxifen, Valproate, etc.); avoiding the use of any type of lipid lowering agents (atorvastatin, lovastatin, pravastatin, etc.); fibrates (gemfibrozil, fenofibrate); lack of malnutrition; have no special diets such as vegan and vegetarian; not drinking alcohol and having over 18 years of age. Exclusion criteria: non-compliance with recommended diet for more than 15 days over 3 months; acute or infectious disease; hospitalization or in cases where the criteria mentioned is. 18 years 70 years Both K76.1 Nonalcoholic fatty liver disease (NAFLD) Treatment - Other Treatment - Drugs The intervention group consisted of 40 patients. Randomly placed in this group. 20 grams per day for 3 months receive olive oil. Diet and recommendations are presented separately for each person. The exact consumption of oil is measured by graded modules. Outcomes measured before and after the intervention. At the beginning and end of study and end of each month, 3-day recall, blood pressure and anthropometric indices will be taken. Blood samples were also collected before and after the intervention. The intervention group consisted of 40 patients. Randomly placed in this group. 20 grams per day for 3 months receive sunflower oil. Diet and recommendations are presented separately for each person. The exact consumption of oil is measured by graded modules. Outcomes measured before and after the intervention. At the beginning and end of study and end of each month, 3-day recall, blood pressure and anthropometric indices will be taken. Blood samples were also collected before and after the intervention. Insulin resistance index. Timepoint: The beginning and end of the study. Method of measurement: blood test. TNF-Alpha. Timepoint: Before the intervention, after intervention. Method of measurement: blood test. Oxidative stress index. Timepoint: Before the intervention, after intervention. Method of measurement: blood test. BMI. Timepoint: Beginning of the study and end of each month. Method of measurement: Balance-Meter. Changes in body composition (fat and muscle mass). Timepoint: Before the intervention, after the intervention. Method of measurement: BIA devices. The degree of fatty liver. Timepoint: Before the intervention, after the intervention. Method of measurement: Ultrasound. Waist Circomfrance. Timepoint: Beginning of the study and end of each month. Method of measurement: Meter. Blood pressure. Timepoint: Beginning of the study and end of each month. Method of measurement: Barometr. School feeding Oil Version Factory School feeding Approved 2015-10-31 University of Medical Sciences, School of Nutrition Shiraz-Iran Razi Shiraz Iran (Islamic Republic of)