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IRCT2017080625732N23 IRCT 2017-08-15 Semnan University of Medical Sciences, Deputy of Research and Technology Evaluation of Sertraline effect for Intradialytic Hypotensionin in the dialytic patients that has been referred to dialyse department of Kowsar hospital in Semnan Evaluation of Sertraline effect for Intradialytic Hypotensionin in the dialytic patients that has been referred to dialyse department of Kowsar hospital in Semnan 2017-01-04 anticipated 100 Complete https://irct.ir/trial/21499 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive. 2-3 hypotension. Intervention 1: Intervention group: receive sertraline 50 mg daily (manufactured by Hayan Darou Company) in during first week and it is increased to 100 mg daily and patients are received sertraline 100 mg daily for another 3 weeks (total 4 weeks: due to that sertraline useful times of effectiveness is 4 weeks). Intervention 2: Control group: receive one placebo tablet daily (totally like sertraline but without therapeutic properties) for 4 weeks.
public Maliheh Yarmohammadi
Semnan University of Medical Sciences, Blvd Basij, Semnan
Semnan Iran (Islamic Republic of) 3514799442 +98 23 3345 1336 are20935@gmail.com Semnan University of Medical Sciences scientific Maliheh Yarmohammadi
Semnan University of Medical Sciences, Blvd Basij, Semnan
Semnan Iran (Islamic Republic of) 3514799442 +98 23 3345 1336 are20935@gmail.com Semnan University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Permanent hemodialysis patients for the at least 3 months that in at least 50 percent of their hemodialysis cases in last 3 months, having intra-dialytic hypotension; perform at least 4 hours hemodialysis for 3 times per week; concentration of dialysis fluid: Na: 106 mEq/L, Ca: 5.2 mEq/L, K: 2 mEq/L and mg: 1 mEq/L, Cl: 111.5 mEq/L, HCO3 3.35; fluid dialysis flow: 500 to 600 ml/min; blood flow: 250 to 300 ml/min; antihypertensive agents received during dialysis; available for at least 8 weeks (study time). Exclusion criteria: Performing hemodialysis in different treatment centers during the time of the study; having mental illness that use the SSRIs drug. no limit no limit Both I95.9 Hypotension, unspecified Treatment - Drugs Placebo Intervention group: receive sertraline 50 mg daily (manufactured by Hayan Darou Company) in during first week and it is increased to 100 mg daily and patients are received sertraline 100 mg daily for another 3 weeks (total 4 weeks: due to that sertraline useful times of effectiveness is 4 weeks) Control group: receive one placebo tablet daily (totally like sertraline but without therapeutic properties) for 4 weeks. Serum creatinine level. Timepoint: Before, 12, 24 and 48 hours after intervention. Method of measurement: Exam. Blood Urea Nitrogen (BUN). Timepoint: Before, 12, 24 and 48 hours after intervention. Method of measurement: Exam. Semnan University of Medical Sciences, Deputy of Research and Technology Approved 2017-01-03 Ethics Committee, Deputy of research and technology, Semnan University of Medical Sciences Semnan University of Medical Sciences, Basij Blvd, Semnan Semnan Iran (Islamic Republic of)