IRCT2017020725732N13 IRCT 2017-05-01 Vice chancellor for research, Semnan University of Medical Sciences Comparison of the Effect of Ondansetron, Dexamethasone and Their Combination in Reducing Nausea and Vomiting Following Laparoscopic Cholecystectomy in patients referred to Semnan Kosar Hospital Comparison of the Effect of Ondansetron, Dexamethasone and Their Combination in Reducing Nausea and Vomiting Following Laparoscopic Cholecystectomy 2016-09-13 anticipated 90 Complete https://irct.ir/trial/21489 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. 2 Nausea and vomiting. Intervention 1: Intervention 1: 30 cases of patients were injected 16 mg of dexamethasone intravenously based on a simple random sampling. Injection was performed by an anesthesiologist who will be unaware of the drugs type before the first surgery incision immediately. The anesthesia were performed with the same way in all three groups. Furthermore, the patient’s nausea and vomiting were checked during 6 and 24 hours after surgery. The patient's recovery period was recorded after surgery. Intervention 2: Intervention 2: 30 cases of patients were injected 4 mg of ondansetron intravenously based on a simple random sampling. Injection was performed by an anesthesiologist who will be unaware of the drugs type before the first surgery incision immediately. The anesthesia were performed with the same way in all three groups. Furthermore, the patient’s nausea and vomiting were checked during 6 and 24 hours after surgery. The patient's recovery period was recorded after surgery. Intervention 3: Intervention 3: 30 cases of patients were injected 4 mg of ondansetron plus 8 mg of dexamethasone intravenously based on a simple random sampling. Injection was performed by an anesthesiologist who will be unaware of the drugs type before the first surgery incision immediately. The anesthesia were performed with the same way in all three groups. Furthermore, the patient’s nausea and vomiting were checked during 6 and 24 hours after surgery. The patient's recovery period was recorded after surgery.