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IRCT2015122425686N1 IRCT 2016-05-10 Vice chancellor for research, Tabriz University of Medical Sciences Effects of the Capparis pickle on Fatty Liver The investigation of the effects of Capparis Spinosa Fruit pickle (Traditional Iranian Medicine product) on Liver Transaminases in Nonalcoholic Fatty Liver Disease (NFLD) 2016-03-10 anticipated 50 Complete https://irct.ir/trial/21439 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Nonalcoholic fatty liver disease. Intervention 1: Intervention 1 : the intervention group In addition to teaching life style and training package similar at baseline and follow up with phone calls weekly, daily intake of 40 mg pickled capers fruit with meals for lunch and dinner. Intervention 2: Intervention 2: teaching life style and training package similar at baseline and follow up with phone calls weekly in the control group.
public Narjes.Khavasi
Central Building, Tabriz University of Medical Sciences, University Street, Tabriz
Tabriz Iran (Islamic Republic of) 5165665931 +98 41 3337 9528 narjes.khavasi@yahoo.com; nxavasi@gmail.com Tabriz University of Medical and Sciences scientific Mohamad Hosein Somi
Central Building, Tabriz University of Medical Sciences, University Street, Tabriz, Iran
Tabriz Iran (Islamic Republic of) 5165665931 +98 41 3337 9528 mhosseinsina@yahoo.com Tabriz University of Medical and Sciences Iran (Islamic Republic of) Inclusion criteria: nonalcoholic fatty liver (elevated SGPTand sonography results); age 12 to 80 years. Exclusion criteria: Hyperlipidemia during treatment or Severe hyperlipidemia; pregnancy and lactation; Coagulopathies; thyroid disease; cirrhosis, viral hepatitis; Overt diabetes; Drugs that affect metabolism or liver enzyme levels such as OCP, Corticosteroid, ..; patients who are hospitalized in the course of treatment and therefore could not continue the treatment; patients who cannot eat pickled capers fruit for various reasons; Patients who cannot adhere to the guidelines recommended in the lifestyle training. 12 years 80 years Both k76.0 Nonalcoholic fatty liver disease (NAFLD) Treatment - Drugs Lifestyle Intervention 1 : the intervention group In addition to teaching life style and training package similar at baseline and follow up with phone calls weekly, daily intake of 40 mg pickled capers fruit with meals for lunch and dinner Intervention 2: teaching life style and training package similar at baseline and follow up with phone calls weekly in the control group SGPT. Timepoint: Before the intervention, the end of the twelfth week intervention. Method of measurement: Blood sample. SGOT. Timepoint: Before the intervention, the end of the twelfth week intervention. Method of measurement: Blood sample. Total chlo. Timepoint: Before the intervention, the end of the twelfth week intervention. Method of measurement: Blood sample. FBS. Timepoint: Before the intervention, the end of the twelfth week intervention. Method of measurement: Blood sample. TG. Timepoint: Before the intervention, the end of the twelfth week intervention. Method of measurement: Blood sample. VLDL. Timepoint: Before the intervention, the end of the twelfth week intervention. Method of measurement: Blood sample. LDL. Timepoint: Before the intervention, the end of the twelfth week intervention. Method of measurement: Blood sample. HDL. Timepoint: Before the intervention, the end of the twelfth week intervention. Method of measurement: Blood sample. Fasting Insulin. Timepoint: Before the intervention, the end of the twelfth week intervention. Method of measurement: Blood sample. Cs-CRP. Timepoint: Before the intervention, the end of the twelfth week intervention. Method of measurement: Blood sample. BMI. Timepoint: Before the intervention, the end of the twelfth week intervention. Method of measurement: Digital weighing scales and measuring the height of meters. Appetite. Timepoint: Before the intervention, the end of the twelfth week intervention. Method of measurement: VAS Questionnaire. Insulin resistance. Timepoint: Before the intervention, the end of the twelfth week intervention. Method of measurement: HOMA Index. Vice chancellor for research, Tabriz University of Medical Sciences Approved 2015-10-26 Ethics Committee of Tabriz University of Medical Sciences No 2 Central Building, Tabriz University of Medical Sciences, University Street, Tabriz,Iran Tabriz Iran (Islamic Republic of)