IRCT2016121925267N4 IRCT 2017-07-26 Vice chancellor for Research, Tehran University of Medical Sciences Evaluating the efficacy of two types of low-carbohydrate diets on weight, metabolic and inflammatory factors in patients with metabolic syndrome Evaluating the efficacy of low-carbohydrate (Paleo diet) and moderate-carbohydrate diet with two delivery mode; “fixed diet plan” vs “calorie counting” on body composition, serum levels of some hepatokines and adipocytokines and flowcytometric analysis of endothelial micro particles (EMPs) in adults with metabolic syndrome: A randomized clinical trial 2017-05-22 anticipated 80 Complete https://irct.ir/trial/21157 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Factorial, Purpose: Treatment, Other design features: Balanced Block Randomization. 2-3 Metabolic Syndrome. Intervention 1: Intervention group 4: Receiving moderate carbohydrate diet with “fixed diet plan” for 12 weeks. Medium-carbohydrate diet is defined as a 40% carbohydrate, 30% protein and 30% fat diet. Intervention 2: Intervention group 3: Receiving moderate carbohydrate diet with calorie counting for 12 weeks. Medium-carbohydrate diet is defined as a 40% carbohydrate, 30% protein and 30% fat diet. Intervention 3: Intervention group 1: Receiving paleo diet with calorie counting for 12 weeks. Low-carbohydrate paleo diet is defined as a 20% carbohydrate, 35% protein and 45% fat diet. Intervention 4: Intervention group 2: Receiving paleo diet with “fixed diet plan” for 12 weeks. Low-carbohydrate paleo diet is defined as a 20% carbohydrate, 35% protein and 45% fat diet.