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IRCT2015112325202N1 IRCT 2016-01-31 parisa shirzad Comparison of the three types of drugs to reduce propofol pain - Comparisson effect of pretreatment with ondansetron, lidocaine and paracetamol drugs on pain reduction due to interavenous injectionof Propofol 2015-07-23 anticipated 164 Complete https://irct.ir/trial/21111 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A Acut pain after propofol injection. Intervention 1: Intervention 1: Paracetamol: Closing pressure cuff on the arm on the same side and blowing tourniquet pressure to 70 mm Hg, partial occlusion of the venous system has been established and this drug will be injected within 10 seconds, after 2 minutes cuff pressure discharge and a quarter of total dose Propofol 1% (2.5 mg kg) of Austria in order freseniuskabi company darman yab daro within 20 seconds will inject from the desired vein. Intervention 2: Intervention 2:ondancetronl: Closing pressure cuff on the arm on the same side and blowing tourniquet pressure to 70 mm Hg, partial occlusion of the venous system has been established and this drug will be injected within 10 seconds, after 2 minutes cuff pressure discharge and a quarter of total dose Propofol 1% (2.5 mg kg) of Austria in order freseniuskabi company darman yab daro within 20 seconds will inject from the desired vein. Intervention 3: Intervention 3: lidocain: Closing pressure cuff on the arm on the same side and blowing tourniquet pressure to 70 mm Hg, partial occlusion of the venous system has been established and this drug will be injected within 10 seconds, after 2 minutes cuff pressure discharge and a quarter of total dose Propofol 1% (2.5 mg kg) of Austria in order freseniuskabi company darman yab daro within 20 seconds will inject from the desired vein. Intervention 4: Control group: distilled water all steps will be similar to the intervention group.
public Parisa Shirzad
Hamadan Medical School
Hamadan Iran (Islamic Republic of) +98 818138378247 Fairyborn7@yahoo.com Hamadan University Of Medical Science scientific Mohammad Zolhavarieh
Shahid Beheshti hospital
Hamadan Iran (Islamic Republic of) +98 81 3838 0092 dsmbszolhavarieh@gmail.com Hamadan University Of Medical Science Iran (Islamic Republic of) Inclusion criteria: " age 18 to 65 years" "patients with ASA class 1 and 2" " patients undergoing elective surgery" Exclusion criteria:" (1) patients with ASA class of 3 or higher 2. Patients with a history of HTN and DM 3. Patients with a history of narcotic or psychotropic abuse or NSAID 4. The patient who are contraindicate for propofol, ondansetron, paracetamol and lidocaine drugs 18 years 65 years Both R52.0A pain, Vomiting, nausia Treatment - Drugs Treatment - Drugs Treatment - Drugs Placebo Intervention 1: Paracetamol: Closing pressure cuff on the arm on the same side and blowing tourniquet pressure to 70 mm Hg, partial occlusion of the venous system has been established and this drug will be injected within 10 seconds, after 2 minutes cuff pressure discharge and a quarter of total dose Propofol 1% (2.5 mg kg) of Austria in order freseniuskabi company darman yab daro within 20 seconds will inject from the desired vein. Intervention 2:ondancetronl: Closing pressure cuff on the arm on the same side and blowing tourniquet pressure to 70 mm Hg, partial occlusion of the venous system has been established and this drug will be injected within 10 seconds, after 2 minutes cuff pressure discharge and a quarter of total dose Propofol 1% (2.5 mg kg) of Austria in order freseniuskabi company darman yab daro within 20 seconds will inject from the desired vein Intervention 3: lidocain: Closing pressure cuff on the arm on the same side and blowing tourniquet pressure to 70 mm Hg, partial occlusion of the venous system has been established and this drug will be injected within 10 seconds, after 2 minutes cuff pressure discharge and a quarter of total dose Propofol 1% (2.5 mg kg) of Austria in order freseniuskabi company darman yab daro within 20 seconds will inject from the desired vein Control group: distilled water all steps will be similar to the intervention group Reduce the pain of Propofol injection. Timepoint: Along with propofol infusion in 20 seconds. Method of measurement: four-point verbal rating scale = VRS) which contains no pain = 0 , mild= 1 , moderate= 2 and severe =score 3 (by tearing or rejection injected organs or patient complain of pain or frown). Check of pain and swelling and allergic reactions of drugs within 2 hours after injection were recorded in questionnair. Timepoint: within 2 hours after injection of drugs. Method of measurement: Observation and question. parisa shirzad Approved 2015-05-23 Ethics committee of Hamadan Univercity of Medical Science shahid fahmideh avenue Hamadan Iran (Islamic Republic of)