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IRCT2015112225191N1 IRCT 2016-01-17 Iran University of Medical Sciences Vice chancellor for research Efficacy of Clozapine in Patients with Prolonged Methamphetamine Induced Psychotic Disorder: A Single-blind Comparison With Olanzapine Efficacy of Clozapine in Patients with Prolonged Methamphetamine Induced Psychotic Disorder: A Single-blind Comparison With Olanzapine in drug abusers 2016-04-04 anticipated 40 Complete https://irct.ir/trial/21103 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 Resistant Psychosis Induced by Methamphetamine. Intervention 1: In the first stage of a medical history and medical examination will be done and then the patient will be taken. Complete blood count tests Valktrvkardyvgram or ECG at baseline for all patients will be performed. For the group treated with clozapine, based on the standard of care protocol venous blood sampling blood cell count every week until the end of the six week study and measurement of liver enzymes is done with and for the group treated with olanzapine retesting of blood samples After six weeks of intravenous treatment Sharveh study done to assess liver enzymes. Patients will be selected by convenience sampling method and randomly divided into two groups of 20 by minimizing a group treated with clozapine and olanzapine will be the second group.  In addition to the above-mentioned questionnaire, a demographic questionnaire made by the researcher, including age, sex, education, duration of abuse, the age of onset of drug use, the type of substance, other drug use, age at onset of psychotic symptoms at their disposal to complete will be placed. Clozapine treatment dose of 6.25 mg up to 450 mg on the first day and will continue. Intervention 2: In the first stage of a medical history and medical examination will be done and then the patient will be taken. CBC tests Valktrvkardyvgram or ECG at baseline for all patients will be performed. For the group treated with olanzapine retesting of blood samples after treatment Sharveh six week study done to assess liver enzymes. Olanzapine dose of 5 mg to 15 mg on the first day and will continue.
public Dr Behnam Shariati
Rasool Hospital, St. Mansouri,, St.Niayesh, Starkhan,Tehran
Tehran Iran (Islamic Republic of) +98 21 6435 2331 behnamshariatimd@gmail.com Iran University of Medical Sciences scientific Dr Behnam Shariati
School of Behavioral Sciences and Health psycho Tehran Psychiatric Institute, Niayesh street,Sattar Khan Street, Tehran
Tehran Iran (Islamic Republic of) +98 21 6435 2331 . Iran University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: 1- A psychotic disorder caused by prolonged use of methamphetamine (more than 1 month psychotic and at the same time cocaine has not); 2- obtaining the informed consent of the patient's guardian; 3- The absence of mental retardation (moderate or severe); 4- Non-organic neurological disease leading to clinical standpoint. Exclusion criteria: 1- If the loss of white blood cells or neutrophils less than 3,000 is less than 1,500; 2- Unwillingness to continue to participate in the study. no limit no limit Both F15 This block contains a wide variety of disorders that differ in severity and clinical form but that are all related to the use of one or more drugs, which may or may not prescribe medicine. The third letter of the code identify the materials involved, and Treatment - Drugs Treatment - Drugs In the first stage of a medical history and medical examination will be done and then the patient will be taken. Complete blood count tests Valktrvkardyvgram or ECG at baseline for all patients will be performed. For the group treated with clozapine, based on the standard of care protocol venous blood sampling blood cell count every week until the end of the six week study and measurement of liver enzymes is done with and for the group treated with olanzapine retesting of blood samples After six weeks of intravenous treatment Sharveh study done to assess liver enzymes. Patients will be selected by convenience sampling method and randomly divided into two groups of 20 by minimizing a group treated with clozapine and olanzapine will be the second group.  In addition to the above-mentioned questionnaire, a demographic questionnaire made by the researcher, including age, sex, education, duration of abuse, the age of onset of drug use, the type of substance, other drug use, age at onset of psychotic symptoms at their disposal to complete will be placed. Clozapine treatment dose of 6.25 mg up to 450 mg on the first day and will continue In the first stage of a medical history and medical examination will be done and then the patient will be taken. CBC tests Valktrvkardyvgram or ECG at baseline for all patients will be performed. For the group treated with olanzapine retesting of blood samples after treatment Sharveh six week study done to assess liver enzymes. Olanzapine dose of 5 mg to 15 mg on the first day and will continue The severity of Symptoms and Psychosis Protests. Timepoint: Baseline, the end of the fourth week and eighth week. Method of measurement: Based on the PANSS Scale. Craving. Timepoint: At baseline, the end of the fourth week and eighth week. Method of measurement: Craving Beliefs Questionnaire (CBQ. Extrapyramidal Side Effects. Timepoint: Baseline, the end of the fourth week and eighth week. Method of measurement: Scale Extrapyramidal Side Effects ((ESRs. none none Iran University of Medical Sciences Vice chancellor for research Approved 2015-09-23 Mental Health Research Center, Iran University of Medical Sciences Ethics Committee School of Behavioral Sciences and Health psycho Tehran Psychiatric Institute, Niayesh street,Sattar Khan Street, Tehran Tehran Iran (Islamic Republic of)