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IRCT2015110824947N1 IRCT 2017-02-06 Zanjan Universiy of Medical Sciences Burn dressing with amniotic membrane Comparison of the therapeutic effect of amniotic membrane dressing with silver sulfadiazine ointment dressings in the management of superficial burns wounds, second degree of trunk and limb Ayatollah in Mousavi Hospital of Zanjan in 2016-2017 2016-12-21 anticipated 50 Complete https://irct.ir/trial/20956 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Degree 2 burn wounds. Intervention 1: In the intervention group burns area are dressing with amniotic membrane. Intervention 2: In the control group burns area are dressing with gauze soaked with silver sulfadiazine ointment.
public Dr Mehran Salehian
Mousavi hospital, Gavazng road
Zanjan Iran (Islamic Republic of) +98 24 3313 0001 mehran.salehian@gmail.com Zanjan Universiy of Medical Sciences scientific Dr. Mohammad Hosein Moghimi
Mousavi hospital, Gavazng road
Zanjan Iran (Islamic Republic of) +98 24 3313 0001 Mohammadhosein_moghimi@yahoo.com Department of Surgery, Zanjan University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: all patients wit; superficial thermal burns grade 2 less than 20% and no burns isolated to the head and neck; lack of burn areas genitalia; stable vital signs; no history of psychiatric disorders in patients with burns; the absence of drug and psychotropic; smoking, no history of heart, kidney and liver problems; no diabetes; no history of malnutrition; not taking corticosteroids or drugs that suppress the immune system; lack of burns inhalation; no history for sulfonamides toxicity; no previous burns in the recent burn site; no evidence of infection in burns and age over 18 years in patients presenting to the emergency department or clinic. Exclusion criteria: allergic reaction to silver sulfadiazine ointment; side effects or sensitivity to amniotic membrane dressing; requirement to wound debridement in the operating room. 18 years 99 years Both T30.2 Burn of second degree, body region unspecified Treatment - Other Treatment - Other In the intervention group burns area are dressing with amniotic membrane In the control group burns area are dressing with gauze soaked with silver sulfadiazine ointment. Epithelializasion. Timepoint: Seven days, 14 days and 30 days after intervention (dressing with amniotic membrane). Method of measurement: Based on the physical examination. Wound infection. Timepoint: Daily visits during hospitalization and based on clinical evidence and cultivation of bending if positive clinical evidence (fever, discharge and cellulite). Method of measurement: Clinical descriptions of daily visits. Analgesia Consumption. Timepoint: Daily during admission. Method of measurement: Medical records. Frequency of dressing exchange. Timepoint: From first until 30th day of the study. Method of measurement: The number of dressing exchange. Wound scar. Timepoint: 30 days after the intervenion. Method of measurement: Physical examination (0 = no scar; 1 = mild ; 2 = moderate ; 3 = severe. Pain. Timepoint: The seventh day after the intervention (dressing with amniotic membrane or silver sulfadiazine ointment). Method of measurement: Visual Analogue Scale. Zanjan Universiy of Medical Sciences Approved 2016-12-20 Zanjan University of Medical Sciences Zanjan University of Medical Sciences, Azadi blvd. Zanjan Iran (Islamic Republic of)